Gourt > Health > Support Groups > Conditions and Diseases > Cancer > Bone Marrow Transplant
Bone marrow transplantation (BMT) or hematopoietic stem cell transplantation (HSCT) is a medical procedure in the field of hematology and oncology that involves transplantation of hematopoietic stem cells (HSC). It is most often performed for people with diseases of the blood or bone marrow, or certain types of cancer. Bone marrow transplantation was pioneered in the 1970's by E. Donnall Thomas whose work was later recognized with a Nobel Prize in Physiology and Medicine. Dr. Thomas' work showed that bone marrow cells infused intravenously could repopulate the bone marrow and produce new blood cells. His work also reduced the likelihood of developing a life-threatening complication called Graft-versus-host disease (GVHD). However it remains a risky procedure and it is reserved for patients with life threatening diseases.
Principles
Most recipients of HSCTs are leukemia patients or others who would benefit from treatment with high doses of chemotherapy or Total body irradiation (TBI). Other patients who receive bone marrow transplants include pediatric cases where the patient has an inborn defect such as severe combined immunodeficiency or congenital neutropenia and was born with defective stem cells. Children or adults with aplastic anemia have lost their stem cells after birth and may not require such high doses of chemotherapy and irradiation prior to a transplant. In this case there is a greater need for immunosuppressive agents. Other conditions that bone marrow transplants are considered for include thalassemia major, sickle-cell disease, myelodysplastic syndrome, lymphoma, and multiple myeloma. More recently non-myeloablative, or so-called "mini transplant" procedures have been developed which do not require such large doses of chemotherapy and radiation. This has allowed HSCT to be conducted in older patients and without the need for hospitalization.
Stem cell collection
Types of donors
There are two major types of bone marrow transplantation. Autologous bone marrow transplantation involves isolation of HSC from a patient, storage of the stem cells in a freezer, medical treatment of the patient that destroys stem cells remaining in the body, and return of the patient's own stored stem cells to their body. Autologous transplants have the advantage of a lower risk of graft rejection, infection and GVHD. Allogeneic bone marrow transplantation involves two people, one is the (normal) donor and one is the (patient) recipient. Allogeneic HSC donors must have a tissue (HLA) type that matches the recipient and, in addition, the recipient requires immunosuppressive medications. Allogeneic transplant donors may be related (usually a sibling) or unrelated volunteers. More on [ Bone marrow transplant ]
Bone Marrow Transplantation :: Hematology
Transplantation Patient Support Groups
RT @JeromeTrammel: Bone Marrow Transplant Needed (Only Blood Donation) Please Help!! http://www.savejenaustin.com/
11121922 (KEISHA) Wed, 23 Dec 2009 06:58:44 -0000
RT @JeromeTrammel: Bone Marrow Transplant Needed (Only Blood Donation) Please Help!! http://www.savejenaustin.com/
Sara Valor: RT @kellylynchring: My 3yr old friend Tyler needs immediate bone marrow transplant & PRAYERS FOR... http://bit.ly/4S8w5f
prayingtogether (Ciprian Gherghescu) Wed, 23 Dec 2009 02:40:52 -0000
Sara Valor: RT @kellylynchring: My 3yr old friend Tyler needs immediate bone marrow transplant & PRAYERS FOR... http://bit.ly/4S8w5f
RT @kellylynchring: My 3yr old friend Tyler needs immediate bone marrow transplant & PRAYERS FOR CHRISTMAS! Story here http://vitalearth ...
KerryPintado (KerryPintado) Wed, 23 Dec 2009 01:55:06 -0000
RT @kellylynchring: My 3yr old friend Tyler needs immediate bone marrow transplant & PRAYERS FOR CHRISTMAS! Story here http://vitalearth ...
RT @Sara_Valor: RT @kellylynchring: My 3yr old friend Tyler needs immediate bone marrow transplant & PRAYERS FOR CHRISTMAS! Story here h ...
Fire_N_Ice_LLC (Kasandra Cherry) Wed, 23 Dec 2009 01:54:58 -0000
RT @Sara_Valor: RT @kellylynchring: My 3yr old friend Tyler needs immediate bone marrow transplant & PRAYERS FOR CHRISTMAS! Story here h ...
RT @kellylynchring: My 3yr old friend Tyler needs immediate bone marrow transplant & PRAYERS FOR CHRISTMAS! Story here http://bit.ly/2qSqZb
Sara_Valor (Sara Valor) Wed, 23 Dec 2009 01:53:50 -0000
RT @kellylynchring: My 3yr old friend Tyler needs immediate bone marrow transplant & PRAYERS FOR CHRISTMAS! Story here http://bit.ly/2qSqZb
RT @kellylynchring: My 3yr old friend Tyler needs immediate bone marrow transplant & PRAYERS FOR CHRISTMAS! Story here http://vitalearth ...
Greetums (Kat Caverly) Wed, 23 Dec 2009 01:52:45 -0000
RT @kellylynchring: My 3yr old friend Tyler needs immediate bone marrow transplant & PRAYERS FOR CHRISTMAS! Story here http://vitalearth ...
Andrews Helpful Hands Foundation Inc - A Massachusetts based organisation which helps families with children who are going through the bone marrow transplant process.
Meta Description: [ Andrews Helpful Hands Foundation financially assists families who have a child with cancer who is in need of a bone marrow transplant to save their life ]
BMT Support Online - An online support organization for people facing or recovering from Bone Marrow Transplantation, their family members, caregivers and friends.
Meta Description: [ BMT SUPPORT ONLINE is an interactive chat for Bone Marrow Transplant
patients, people who are facing having a BMT, family members of those patients, care
givers and friends to come together to discuss our experiences with this difficult but
potentially life saving procedure. We tal... ]
Bone Marrow Transplant Support Group - Information and links to resources for BMT, Leukemia, Lymphoma, fatigue, and stem cell. Patient stories, message board, and a glossary of terms available.
Meta Description: [ Stem cell and Bone Marrow Transplant information & links, forum, patient stories, news, Glossary of Terms ]
The Bruce Denniston Bone Marrow Society - A registered charity raising money to help match donors to patients needing bone marrow transplants. It also assists patients with transplant-related expenses. Information on the society, its history and activities.
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