.png | width = 218 | CAS_number = 57-22-7 | ATC_prefix = L01 | ATC_suffix = CA02 | ATC_supplemental = | PubChem = 5978 | DrugBank = APRD00495 | chemical_formula = C₄₆H₅₆N₄O₁₀ | molecular_weight = 824.958 g/mol | bioavailability = | protein_bound = ~75% | metabolism = hepatic | elimination_half-life = 19-155 hours | pregnancy_category = | legal_status = Rx-only | routes_of_administration = | excretion = mostly biliary, 10% in urine }} Vincristine (Oncovin®) is an alkaloid from the Madagascar periwinkle (Catharanthus roseus, formerly Vinca rosea and hence its name). It is used in chemotherapy.

Mode of action

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Tubulin is a structural protein which polymerises to form microtubules. The cell cytoskeleton and mitotic spindle, amongst other things, are made of microtubules. Vincristine binds to tubulin dimers causing disassembly of microtubule structures. Disruption of the microtubules arrests mitosis in metaphase. The vinca alkaloids therefore affect all rapidly dividing cell types, including cancer cells but also as intestinal epithelium and bone marrow.

Side effects

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The main side-effects of vincristine are peripheral neuropathy and constipation. The latter may require laxatives, while the former can be a reason to reduce the dose of vincristine.

More on [ Vincristine ]

Vincristine - Twitter Search

evaluating dactinomycin & vincristine in young ppl w/ cancer http://bit.ly/5G6FC4
paidtrials (US Clinical Trials) Fri, 11 Dec 2009 11:14:53 -0000
evaluating dactinomycin & vincristine in young ppl w/ cancer http://bit.ly/5G6FC4
キョウチクトウの毒性成分はoleandrin、強心配糖体か。キョウチクトウ科は天然物化学者ならピンとくる植物が豊富。ニチニチソウ→vincristine, インドジャボク→reserpineなど。
biochem_fan (Biochem fan) Fri, 11 Dec 2009 10:04:51 -0000
キョウチクトウの毒性成分はoleandrin、強心配糖体か。キョウチクトウ科は天然物化学者ならピンとくる植物が豊富。ニチニチソウ→vincristine, インドジャボク→reserpineなど。
vincristine, dactinomycin, & cyclophosphamide w/ or w/o radiation thrpy in treating ppl w/ newly diagnosed low-risk http://bit.ly/7rmYgc
paidtrials (US Clinical Trials) Thu, 10 Dec 2009 05:22:52 -0000
vincristine, dactinomycin, & cyclophosphamide w/ or w/o radiation thrpy in treating ppl w/ newly diagnosed low-risk http://bit.ly/7rmYgc
vincristine, carboplatin, & etoposide or observation only in treating ppl who have undergone surgery 4 newly diagnosed http://bit.ly/4LVCWR
paidtrials (US Clinical Trials) Wed, 09 Dec 2009 09:30:55 -0000
vincristine, carboplatin, & etoposide or observation only in treating ppl who have undergone surgery 4 newly diagnosed http://bit.ly/4LVCWR
safety & tolerability clofarabine, etoposide, cyclophosphamide, peg-asparaginase, & vincristine in pediatric acute http://bit.ly/6Pmvjq
cancertrials_ (Cancer Trials) Wed, 09 Dec 2009 05:30:53 -0000
safety & tolerability clofarabine, etoposide, cyclophosphamide, peg-asparaginase, & vincristine in pediatric acute http://bit.ly/6Pmvjq
safety & tolerability clofarabine, etoposide, cyclophosphamide, peg-asparaginase, & vincristine in pediatric acute http://bit.ly/5k8F6X
bostontrials (Boston Trials) Wed, 09 Dec 2009 04:38:54 -0000
safety & tolerability clofarabine, etoposide, cyclophosphamide, peg-asparaginase, & vincristine in pediatric acute http://bit.ly/5k8F6X

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