Ursodiol (trade names
Actigall,
Ursofalk,
Urso,
Urso Forte) is a
bile acid found in large quantities in
bear bile; it also occurs naturally in human bile in smaller quantities.
The drug reduces cholesterol absorption and is used to dissolve gallstones in patients who want an alternative to surgery. The drug is very expensive, however, and if the patient stops taking it, the gallstones recur. For these reasons, it has not supplanted surgical treatment by cholecystectomy. It is also the recommended treatment for Primary biliary cirrhosis, and other cholestatic diseases, and the primary medicine given to children with biliary atresia.
Mechanism of action
Ursodiol, whose chemical name is ursodeoxycholic acid, reduces elevated liver enzyme levels by facilitating bile flow through the liver and protecting liver cells.
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[ Ursodiol ]
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