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Trazodone (Desyrel®, Trittico®, Thombran®, Trialodine®) is a psychoactive compound with sedative, anxiolytic, and antidepressant properties. The manufacturer claims that the antidepressant activity becomes evident in the first week of therapy. Trazodone has less prominent anticholinergic (dry mouth, constipation, tachycardia) and adrenolytic (hypotension, male sexual problems) side effects than most tricyclic antidepressants. The incidence of nausea and vomiting observed with Trazodone is relatively low compared to SSRIs.
Mechanism of action
Trazodone is a serotonin reuptake inhibitor and is also a 5-HT2 receptor antagonist. However, in contrast to the selective serotonin reuptake inhibitors such as fluoxetine (Prozac®), trazodone's antidepressant effects may be due to its antagonistic effect at the 5-HT2 receptor site (PMID 1365657).
Pharmacokinetics
Trazodone is well absorbed after oral administration with mean peak blood levels obtained at approximately 1 hour after ingestion. Absorption is somewhat delayed and enhanced by food. The mean blood elimination half-life is biphasic: the first phase's half-life is 3-6 hours, and the following phase's half-life is 5-9 hours. The drug is extensively metabolized with 3 or 4 major metabolites having been identified in man. Approximately 70-75% of C14-labelled trazodone was found to be excreted in the urine within 72 hours (PMID 1037253). Trazodone is highly protein-bound. More on [ Trazodone ]
Antidepressants :: Drugs and Medications
trazodone=yay
EyesSetToLewis (lewis holler) Sat, 07 Nov 2009 19:32:57 -0000
trazodone=yay
Took two trazodone...slept for 2 hrs....only to now be awake. :-(
jennlynnjones (Jennifer Jones) Sat, 07 Nov 2009 05:37:32 -0000
Took two trazodone...slept for 2 hrs....only to now be awake. :-(
@hetzakoatl Synthetic quick release melatonin 3mg & (off label) trazodone hydrochloride 50mg, the latter wasnt keen on but willing to try
BearNoiz (GavDoff) Fri, 06 Nov 2009 13:01:01 -0000
@hetzakoatl Synthetic quick release melatonin 3mg & (off label) trazodone hydrochloride 50mg, the latter wasnt keen on but willing to try
had a great night's sleep - upping the dosage of my trazodone really worked!! yay!! slept for 8 whole hours (admittedly on sofa)
RosieBrent (Rosie Brent) Fri, 06 Nov 2009 08:57:30 -0000
had a great night's sleep - upping the dosage of my trazodone really worked!! yay!! slept for 8 whole hours (admittedly on sofa)
Capt'n morgan plus celexa and trazodone...GREAT mix right now!!!
TweetaMike (Mike Hatcher) Fri, 06 Nov 2009 07:22:15 -0000
Capt'n morgan plus celexa and trazodone...GREAT mix right now!!!
Reading Calvin W. Schwabe's 1979 classic Unmentionable Cuisine as I wait for the Trazodone to kick in. Stewed squirrel, sheep pancreas. Mmm
slicksean (Sean Kennedy) Fri, 06 Nov 2009 05:35:04 -0000
Reading Calvin W. Schwabe's 1979 classic Unmentionable Cuisine as I wait for the Trazodone to kick in. Stewed squirrel, sheep pancreas. Mmm
Trazodone - Patient information about this antidepressant medication. U.S. brand names: Desyrel, Trazon, Trialodine. Other countries: Beneficat; Bimaran; Deprax; Desirel; Manegan; Molipaxin; Pragmarel; Sideril; Taxagon; Thombran; Trazalon; Trazolan; Trazonil; Trittico.
Meta Description: [ Trazodone, Desyrel, Trazon, Trialodine, is a modified cyclic antidepressant. Uses, side effects, dosages. ]
Trazodone (Desyrel) - Summary of uses, side effects, and other information for patients.
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