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Trazodone (Desyrel®, Trittico®, Thombran®, Trialodine®) is a psychoactive compound with sedative, anxiolytic, and antidepressant properties. The manufacturer claims that the antidepressant activity becomes evident in the first week of therapy. Trazodone has less prominent anticholinergic (dry mouth, constipation, tachycardia) and adrenolytic (hypotension, male sexual problems) side effects than most tricyclic antidepressants. The incidence of nausea and vomiting observed with Trazodone is relatively low compared to SSRIs.
Mechanism of action
Trazodone is a serotonin reuptake inhibitor and is also a 5-HT2 receptor antagonist. However, in contrast to the selective serotonin reuptake inhibitors such as fluoxetine (Prozac®), trazodone's antidepressant effects may be due to its antagonistic effect at the 5-HT2 receptor site (PMID 1365657).
Pharmacokinetics
Trazodone is well absorbed after oral administration with mean peak blood levels obtained at approximately 1 hour after ingestion. Absorption is somewhat delayed and enhanced by food. The mean blood elimination half-life is biphasic: the first phase's half-life is 3-6 hours, and the following phase's half-life is 5-9 hours. The drug is extensively metabolized with 3 or 4 major metabolites having been identified in man. Approximately 70-75% of C14-labelled trazodone was found to be excreted in the urine within 72 hours (PMID 1037253). Trazodone is highly protein-bound. More on [ Trazodone ]
Antidepressants :: Drugs and Medications
@DissolvedGrl99 I've been taking trazodone for years. It doesn't interfere w/ meds. It's an antidepressant w/ sedating properties.
bloggochicago (Barb Natividad) Sat, 19 Dec 2009 20:56:31 -0000
@DissolvedGrl99 I've been taking trazodone for years. It doesn't interfere w/ meds. It's an antidepressant w/ sedating properties.
@lostfnords if I quit self medicating and trazodone for depression I'm eligible for an #adhd clinical study.. not likely
heartsinspyre (Asraiya On Fire) Sat, 19 Dec 2009 12:04:03 -0000
@lostfnords if I quit self medicating and trazodone for depression I'm eligible for an #adhd clinical study.. not likely
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Nightmares & only half sleep all night. Can barely hold myself up. Maybe Trazodone not working anymore. Must rest.
FrostyPixie (Cordellia Rose) Thu, 17 Dec 2009 16:47:24 -0000
Nightmares & only half sleep all night. Can barely hold myself up. Maybe Trazodone not working anymore. Must rest.
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Dear trazodone, please work faster!
Tolerogen (Tolerogen) Thu, 17 Dec 2009 08:03:50 -0000
Dear trazodone, please work faster!
Trazodone - Patient information about this antidepressant medication. U.S. brand names: Desyrel, Trazon, Trialodine. Other countries: Beneficat; Bimaran; Deprax; Desirel; Manegan; Molipaxin; Pragmarel; Sideril; Taxagon; Thombran; Trazalon; Trazolan; Trazonil; Trittico.
Meta Description: [ Trazodone, Desyrel, Trazon, Trialodine, is a modified cyclic antidepressant. Uses, side effects, dosages. ]
Trazodone (Desyrel) - Summary of uses, side effects, and other information for patients.
