Trandolapril is an ACE inhibitor used to treat high blood pressure, it may also be used to treat other conditions. It is marketed by Abbott Laboratories with the brand name Mavik®.

Pharmacology

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Trandolapril is a prodrug that is deesterified to trandolaprilat. It is believed to exert its antihypertenive effect through the renin-angiotensin-aldosterone system. Trandolapril has a half life of about 6 hours, and trandolaprilat has a half life of about 10. Trandolaprilat has about 8 times the activity of its parent drug. Approximately 1/3 of Trandolapril and its metabolites are excreted in the urine, and about 2/3 of Trandolapril and its metabolites are excreted in the feces. Serum protein binding of trandolapril is about 80%.

Clinical use

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Its mode of action, indications, side-effects and contraindications are as those of all ACE inhibitors. Two to four (2-4) mg, once daily, is the typical dose range.

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who makes Trandolapril and Verapamil and when was it made first? http://bit.ly/69feMc
cumlist (vani fread) Fri, 25 Dec 2009 15:58:24 -0000
who makes Trandolapril and Verapamil and when was it made first? http://bit.ly/69feMc

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