Thrombin (activated Factor II (IIa)) is a coagulation protein that has many effects in the coagulation cascade. It is a serine protease () that converts soluble fibrinogen into insoluble strands of fibrin.

Generation

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Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated Factor X (Xa). The activity of factor Xa is greatly enhanced by binding to activated Factor V (Va), termed the prothrombinase complex. Prothrombin is produced in the liver and is post-translationally modified in a vitamin K-dependent reaction that converts ten glutamic acids on prothrombin to gamma-carboxyglutamic acid (Gla). In the presence of calcium, the gamma-carboxyglutamic acid residues promote the binding of thrombin to phospholipid bilayers. Deficiency of vitamin K or administration of the anticoagulant warfarin inhibits the production of gamma-carboxyglutamic acid residues, slowing the activation of the coagulation cascade.

Action

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Coagulation cascade

Thrombin converts fibrinogen to an active form that assembles into fibrin. Thrombin also activates factor XI, factor V and factor VIII. This positive feedback accelerates the production of thrombin.

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Bayer Returns Commercial Rights Covering Human Thrombin Therapy to ZymoGenetics http://bit.ly/64FfUR
GENbio (GEN Online) Tue, 22 Dec 2009 17:11:16 -0000
Bayer Returns Commercial Rights Covering Human Thrombin Therapy to ZymoGenetics http://bit.ly/64FfUR
Serotonin, thromboplastin, prothrombin, thrombin, fibrin, fibrinogen. Too many fancy words. How will I remember? *Dies*
Glamourousa (Ayse) Tue, 22 Dec 2009 07:55:52 -0000
Serotonin, thromboplastin, prothrombin, thrombin, fibrin, fibrinogen. Too many fancy words. How will I remember? *Dies*
twice-daily oral direct thrombin inhibitor dabigatran etexil8 in long term prevention of recurrent symptomatic vte http://bit.ly/8SKgPN
_clinical_trial (Clinical Trials) Sun, 20 Dec 2009 05:06:43 -0000
twice-daily oral direct thrombin inhibitor dabigatran etexil8 in long term prevention of recurrent symptomatic vte http://bit.ly/8SKgPN
twice-daily oral direct thrombin inhibitor dabigatran etexil8 in long term prevention of recurrent symptomatic vte http://bit.ly/8SKgPN
goclinicaltrial (Clinical Trials) Sun, 20 Dec 2009 04:42:37 -0000
twice-daily oral direct thrombin inhibitor dabigatran etexil8 in long term prevention of recurrent symptomatic vte http://bit.ly/8SKgPN
Thrombin(Coagulation factor II)- US:Court denies King Pharmaceuticals’ injunction motions against ZymoGenetics in tm suit http://is.gd/5rdIe
IPThinkTank (DuncanBucknell) Sat, 19 Dec 2009 00:00:17 -0000
Thrombin(Coagulation factor II)- US:Court denies King Pharmaceuticals’ injunction motions against ZymoGenetics in tm suit http://is.gd/5rdIe
observational stdy assessing impact of exposure 2 thrombin-jmi® on coagulation parameters. http://bit.ly/71liTL
usclinicaltrial (US Clinical Trials) Wed, 16 Dec 2009 16:11:00 -0000
observational stdy assessing impact of exposure 2 thrombin-jmi® on coagulation parameters. http://bit.ly/71liTL

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