Thiothixene (sold as Navane®) is a thioxanthene drug used as a typical antipsychotic medication. It is a thioxanthene derivative and is the cis isomer of N,Ndimethyl- 9-^* thioxanthene-2-sulfonamide.

Although widely used in the treatment of schizophrenia for several decades, thiothixene is seldom used today in favor of atypical antipsychotics such as olanzapine.