Thioridazine is a piperidine phenothiazine antipsychotic drug and is used in the treatment of schizophrenia and psychosis.

Thioridazine is a typical low-potency neuroleptic that is slightly less potent than chlorpromazine. It has a halflife of 7 to 13 hours. (Other sources have 16 to 24 hours.) It has the advantage of a low incidence of early and late extrapyramidal side-effects (tardive dyskinesia). In this regard it is very similar to the atypical neuroleptic clozapine (Clozaril®). Thioridazine has also intrinsic mild to moderate antidepressant properties. It has antiemetic properties. Sedation is said to be less pronounced compared with chlorpromazine.

Indications

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Previous additional indications were agitated depression, tension and anxiety linked to alcohol withdrawal and dysphoria of epileptic patients. It had even (Melleretten® in Europe) an indication for the treatment of psychosis in children and adolescents (10mg to 60mg daily).

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