Tioguanine (INN), formerly Thioguanine (BAN), is a drug that is used in the treatment of cancer. It belongs to the family of drugs called antimetabolites. It is a guanine analog. Its principal use is in acute leukaemias and chronic myeloid leukaemia.

Pharmacology

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As a guanine analogue, it is transformed inside the cell into to 6-thioguanilyic acid (TGMP) which, by pseudofeedback interference with purine biosynthesis, interferes with the synthesis of guanine nucleotides. Some of its activity may also be due to the incorporation of thioguanine nucleotides into both RNA and DNA, but the end result is inducing cell cycle arrest and apoptosis.

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Heme/Onc: DNA incorporation of 6-thioguanine nucleotides during maintenance therapy of childhood acute lymphoblastic leu http://url4.eu/uyF2
MDLinx (Sandeep Pulim MD) Sat, 12 Dec 2009 11:29:55 -0000
Heme/Onc: DNA incorporation of 6-thioguanine nucleotides during maintenance therapy of childhood acute lymphoblastic leu http://url4.eu/uyF2
Peds: DNA incorporation of 6-thioguanine nucleotides during maintenance therapy of childhood acute lymphoblastic leukaem http://url4.eu/uy9p
MDLinx (Sandeep Pulim MD) Sat, 12 Dec 2009 11:25:05 -0000
Peds: DNA incorporation of 6-thioguanine nucleotides during maintenance therapy of childhood acute lymphoblastic leukaem http://url4.eu/uy9p

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