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Thalidomide is a drug that was sold during the late 1950s and 1960s as a sleeping aid and to pregnant women as an antiemetic to combat morning sickness and other symptoms. It was synthesized in West Germany in 1953 and marketed by the Stolberg-near-Aachen-based pharmaceutical company Grünenthal from October 1, 1957 to 1961, mainly in Germany and Britain. It was available in almost fifty countries, although not in the United States, under at least forty names (such as Distaval, Talimol, Kevadon, Nibrol, Sedimide, Quietoplex, Contergan, Neurosedyn, Softenon, etc.).
It was later (1960–61) found to be teratogenic in fetal development, most visibly as a cause of amelia or phocomelia, especially if taken during the first 25 to 50 days of pregnancy. Around 15,000 children were affected by thalidomide, of whom about 12,000 in 46 countries were born with birth defects, with only 8,000 of them surviving past the first year of life. Many of these survivors are still alive, nearly all with disabilities caused by the drug. In 2003, a World Health Organization newsletter cited evidence that the disabilities and deformities in many thalidomide survivors may be passed on to the survivor's own children through DNA, but many discount this as scientifically unfounded. Those deformed by thalidomide are sometimes referred to (or self-described) as thalidomiders or the derogatory abbreviative, "Flids". In Germany, where it was marketed as Contergan, the term Contergankind was coined to describe affected children.
Thalidomide was banned for its initial intended use as sedative. However, it has been found to be effective for other indications such as for leprosy and multiple myeloma. As a result thalidomide analogs are being developed with the intent to offer effective drugs that are safe.
More on [ Thalidomide ]
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ram_lidia (ç¾ å®) Thu, 24 Dec 2009 15:00:29 -0000
メリー苦しみます！ クリスマスプレゼント（笑）的ななにか【http://shindou.himegimi.jp/Thalidomide_Sour.htm】
Thalidomide survivors to get 20m
Endicosoft (Endicosoft Media) Thu, 24 Dec 2009 14:49:16 -0000
Thalidomide survivors to get 20m
Unfortunate headline 'Thalidomide survivors to get big hand-out'
MitchellSt (Mitchell Stirling) Thu, 24 Dec 2009 14:42:27 -0000
Unfortunate headline 'Thalidomide survivors to get big hand-out'
£20m to help thalidomide survivors http://bit.ly/4N26X3
newsfromreading (Paul Chaston) Thu, 24 Dec 2009 14:24:29 -0000
£20m to help thalidomide survivors http://bit.ly/4N26X3
Solicitors Blog: £20 million support package for thalidomide survivors http://bit.ly/6aRWIb #solicitors
yell_solicitors (Yell_Solicitors) Thu, 24 Dec 2009 13:36:08 -0000
Solicitors Blog: £20 million support package for thalidomide survivors http://bit.ly/6aRWIb #solicitors
BBC Headline : 'Thalidomide survivors to get £20m' - I was shocked, I expected a small hand out.
benburling (Benjamin Burling) Thu, 24 Dec 2009 12:48:10 -0000
BBC Headline : 'Thalidomide survivors to get £20m' - I was shocked, I expected a small hand out.
Thalidomide - Historical and clinical information about this drug.
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Thalidomide - Short article about this drug, its history of causing birth defects, its current uses, and limitations on its use. From US Center for the Evaluation of Risks to Human Reproduction.
Thalidomide - Annotated collection of English and German web resources providing information on the drug's physico-chemical properties, effects, side effects, the German Contergan disaster in the early 1960s, and the current use of thalidomide.
Meta Description: [ Annotated collection of English and German web resources providing information on the physico-chemical properties of thalidomide, its effects, and the current use of the drug. ]
Thalomid (Thalidomide) - Description of this medication, focused on its use in treating myeloma.
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