Tacrolimus (also FK-506 or Fujimycin) is a 23-membered macrolide lactone discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.

It is an immunosuppressive drug whose main use is after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection.

It is also used in a topical preparation in the treatment of severe atopic dermatitis (often called "eczema"), as have cyclosporin and azathioprine with much less success. It has also been used after bone marrow transplants and for severe refractory uveitis.

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