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Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor (anticholinesterase). It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease, and was marketed under the trade name Cognex. Tacrine was first synthesised by Adrien Albert at the University of Sydney.
Clinical use
Tacrine was the prototypical cholinesterase inhibitor for the treatment of Alzheimer's disease. Studies have found that it may have a small beneficial effect on cognition and other clinical measures, though adequate study data is limited and the clinical relevance of these findings is unclear.Qizilbash N, Whitehead A, Higgins J, et al. Cholinesterase inhibition for Alzheimer disease: a meta-analysis of the tacrine trials. JAMA 1998;280(20):1777-82. PMID 9842955Rang HP, Dale MM, Ritter JM, Moore PK. Pharmacology, 5th edition. Edinburgh: Churchill Livingstone; 2003..
The use of tacrine is limited by poor oral bioavailability, the necessity for four-times daily dosing, and considerable adverse drug reactions (including nausea, diarrhoea, urinary incontinence and hepatotoxicity) such that few patients could tolerate therapeutic doses.Sweetman S, editor. Martindale: the complete drug reference, 34th ed. London: Pharmaceutical Press; 2004. ISBN 0-85369-550-4
More on [ Tacrine ]
Drug Facts: Cognex (tacrine) http://t.co/tFPvwtNH #alzheimers #dementia
FisherCenter (Alzheimer's Research) Sun, 05 Feb 2012 13:11:40 -0000
Drug Facts: Cognex (tacrine) http://t.co/tFPvwtNH #alzheimers #dementia
@3mma3lsafty wanna tacrine ?????
daisy2497 (Daisy Sarah Evans) Thu, 02 Feb 2012 20:46:06 -0000
@3mma3lsafty wanna tacrine ?????
Tacrine - familydoctor.org - Information for patients in English and Spanish.
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