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In chemistry, the sulfonamide functional group is -S(=O)2-NH2, a sulfone group connected to an amine group.

A sulfonamide (compound) is a compound that contains this group. The general formula is RSO2NH2, where R is some organic group. For example, "methanesulfonamide" is CH3SO2NH2. Any sulfonamide can be considered as derived from a sulfonic acid by replacing a hydroxyl group with an amine group.

In medicine, the term "sulfonamide" is sometimes used as a synonym for sulfa drug, a derivative or variation of sulfanilamide.

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Sulfadiazine - A sulfa drug used in combination with pyrimethamine and leucovorin as maintenance treatment to prevent recurrence of toxoplasmosis. (Microsulfon)

Sulfadoxine - An antibiotic that has been used to prevent PCP. It may also be effective in preventing toxoplasmosis.(Fansidar).

Sulfamethazine - One of a class of drugs called sulfonamides used in combination to treat a variety of infections.(Triple Sulfa, Dayto Sulf, Gyne-Sulf, Sultrin, Trysul, VVS).

Sulfamethoxazole - For people with HIV disease, this drug is usually given in a combination form for prevention of PCP.(Gantanol, Urobak).

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