Streptokinase is an extracellular metallo-enzyme produced by beta-haemolytic streptococcus and is used as an effective and cheap clot-dissolving medication in some cases of myocardial infarction (heart attack) and pulmonary embolism.
It belongs to a group of medicines known as fibrinolytics, and works by cleaving plasminogen and producing plasmin. The half life of Streptokinase is six hours.
Plasmin is produced in the blood to break down the major constituent of blood clots fibrin, therefore dissolving clots once they have fulfilled their purpose in stopping bleeding. Extra production of plasmin caused by streptokinase breaks down unwanted blood clots, for example, in the lungs (pulmonary embolism).
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DrugDigest: Streptokinase ( Streptase ) - Information on dosage, usage, side effects, interactions, and drug comparisons, including generics when available.
Streptokinase - Prescribing information.
Streptokinase for Acute Ischemic Stroke - Article describing the premise and results of the Multicentre Acute Stroke Trial - Italy Group, a randomised controlled trial of streptokinase, aspirin, and combination of both in treatment of acute ischaemic stroke.
Meta Description: [ Randomised controlled trial of streptokinase, aspirin, and combination of both in treatment of acute ischaemic stroke. Lancet 1996;346:1509-14. Journal Club on the Web. ]