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Stavudine (2'-3'-didehydro-2'-3'-dideoxythymidine, d4T, brand name Zerit®) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.

History


Stavudine was approved by the U.S. Food and Drug Administration (FDA) in Jun 24, 1994 for adults and in Sep 6, 1996 for pediatric use and again as an extended-release version for once-a-day dosing in 2001. The fourth antiretroviral drug on the market, its patent will expire in the United States on 2008-06-25.

Mechanism of action


Stavudine is an analog of thymidine. It is phosphorylated by cellular kinases into active triphosphate. Stavudine triphosphate inhibits the HIV reverse transcriptase by competing with natural substrate, thymidine triphosphate. It also causes termination of DNA synthesis by incorporating into it.

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.: Cerebrospinal-fluid HIV-1 RNA and drug concentrations after treatment with lamivudine plus zidovudine or stavudine. http://bit.ly/4wa5qm
_familymedicine (John Johnston) Thu, 22 Oct 2009 07:39:06 -0000
.: Cerebrospinal-fluid HIV-1 RNA and drug concentrations after treatment with lamivudine plus zidovudine or stavudine. http://bit.ly/4wa5qm
.: Cerebrospinal-fluid HIV-1 RNA and drug concentrations after treatment with lamivudine plus zidovudine or stavudine. http://bit.ly/4sFd8Q
_familymedicine (John Johnston) Thu, 22 Oct 2009 07:39:05 -0000
.: Cerebrospinal-fluid HIV-1 RNA and drug concentrations after treatment with lamivudine plus zidovudine or stavudine. http://bit.ly/4sFd8Q

 
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DrugDigest: Stavudine ( Zerit ) - Information on dosage, usage, side effects, interactions, and drug comparisons, including generics when available.

Stavudine - a.k.a. d4T, Zerit.

Stavudine - (d4T, Zerit)
Meta Description: [ stavudine (d4T, Zerit) ]

Zerit - Information about Zerit, HIV, side effects, coping tips, glossary terms, and resource links.
Meta Description: [ Bristol-Myers Squibb is a global pharmaceutical company whose mission is to extend and enhance human life by developing innovative medicines and health care products. ]

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