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Stavudine (2'-3'-didehydro-2'-3'-dideoxythymidine, d4T, brand name Zerit®) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.
History
Stavudine was approved by the U.S. Food and Drug Administration (FDA) in Jun 24, 1994 for adults and in Sep 6, 1996 for pediatric use and again as an extended-release version for once-a-day dosing in 2001. The fourth antiretroviral drug on the market, its patent will expire in the United States on 2008-06-25.
Mechanism of action
Stavudine is an analog of thymidine. It is phosphorylated by cellular kinases into active triphosphate. Stavudine triphosphate inhibits the HIV reverse transcriptase by competing with natural substrate, thymidine triphosphate. It also causes termination of DNA synthesis by incorporating into it. More on [ Stavudine ]
Stavudine should discontinue 4 HIV patients- WHO
shahmersing (Shahrulnizam Jimat) Wed, 02 Dec 2009 04:58:30 -0000
Stavudine should discontinue 4 HIV patients- WHO
Countries should start phasing out stavudine (d4T) as 1st-line tx bc of toxicity. Zidovudine (AZT)-or tenofovir (TDF) regimens are preferred
elena_ivanina (elena ivanina) Tue, 01 Dec 2009 13:30:30 -0000
Countries should start phasing out stavudine (d4T) as 1st-line tx bc of toxicity. Zidovudine (AZT)-or tenofovir (TDF) regimens are preferred
WORLD AIDS DAY!-->WHO guidelines urge phaseout use of stavudine or d4T-major HIV drug-Says drug causes long-term,irreversible side-effects.
Niteowl009 (Niteowl009) Tue, 01 Dec 2009 10:33:03 -0000
WORLD AIDS DAY!-->WHO guidelines urge phaseout use of stavudine or d4T-major HIV drug-Says drug causes long-term,irreversible side-effects.
La OMS pide retirar el fármaco más utilizado contra el VIH: El organismo advierte que el Stavudine, utilizado p.. http://bit.ly/7CGZjQ
farodevigo (farodevigo) Tue, 01 Dec 2009 07:17:25 -0000
La OMS pide retirar el fármaco más utilizado contra el VIH: El organismo advierte que el Stavudine, utilizado p.. http://bit.ly/7CGZjQ
The W.H.O has issued a warning about the use of AIDS drug, Stavudine - due to its "long-term, irreversible" side effects -- in patients
SAfmnews (SAfm news ) Tue, 01 Dec 2009 07:13:44 -0000
The W.H.O has issued a warning about the use of AIDS drug, Stavudine - due to its "long-term, irreversible" side effects -- in patients
Major HIV drug should be phased out: WHO: According to the WHO, countries should phase out Stavudine and use le.. http://bit.ly/5R8oG8
tonya3000 (tonya bell) Mon, 30 Nov 2009 20:46:52 -0000
Major HIV drug should be phased out: WHO: According to the WHO, countries should phase out Stavudine and use le.. http://bit.ly/5R8oG8
DrugDigest: Stavudine ( Zerit ) - Information on dosage, usage, side effects, interactions, and drug comparisons, including generics when available.
Stavudine - a.k.a. d4T, Zerit.
Stavudine - (d4T, Zerit)
Meta Description: [ stavudine (d4T, Zerit) ]
Zerit - Information about Zerit, HIV, side effects, coping tips, glossary terms, and resource links.
Meta Description: [ Bristol-Myers Squibb is a global pharmaceutical company whose mission is to extend and enhance human life by developing innovative medicines and health care products. ]
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