Spironolactone (marketed as Aldactone®, Novo-Spiroton®, Spiractin®, Spirotone®, or Berlactone®) is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat low-renin hypertension, hypokalemia, and Conn's syndrome. On its own, spironolactone is only a weak diuretic, but it can be combined with other diuretics. Due to its anti-androgen effect, it can also be used to treat hirsutism, and is a common component in hormone therapy for male-to-female transgendered people. Also used for treating hair loss.

Mechanism of action

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Spironolactone inhibits the effect of aldosterone by competing for intracellular aldosterone receptor in the distal tubule cells. This increases the secretion of water and sodium, while decreasing the excretion of potassium. Spironolactone has a fairly slow onset of action, taking several days to develop and similarly the effect diminishes slowly. Spironolactone has anti-androgen activity by binding to the androgen receptor and thus preventing it to interact with dihydrotestosterone.Antiandrogen effect ^*

Pharmacokinetics

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Spironolactone is fairly rapidly absorbed from the gastrointestinal tract. It is also rapidly metabolised and bound in plasma proteins. Many of its metabolites are also active and one of them, canrenone as potassium canrenoate, is used parenterally when rapid effect is needed. Spironolactone's half-life is only 10 minutes, but canrenone's half-life is 10 to 35 hours, depending on the dose. The main elimination route is in the urine and some also in the bile.

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Time for the estrogen and the spironolactone!
katie_berger (Katie Berger) Sun, 22 Nov 2009 00:11:28 -0000
Time for the estrogen and the spironolactone!
Is Spironolactone The Only Option for Women Over 35 With Acne ...: In the 2004 May/June edition of the American.. http://bit.ly/RV2nE
SusanBZ46 (Susan Zimm) Thu, 19 Nov 2009 10:35:27 -0000
Is Spironolactone The Only Option for Women Over 35 With Acne ...: In the 2004 May/June edition of the American.. http://bit.ly/RV2nE
Int Med: Spironolactone and Chlorthalidone in Uncontrolled Elderly Hypertensive Patients Treated with Calcium Antagonist http://url4.eu/muj8
MDLinx (Sandeep Pulim MD) Thu, 19 Nov 2009 10:28:42 -0000
Int Med: Spironolactone and Chlorthalidone in Uncontrolled Elderly Hypertensive Patients Treated with Calcium Antagonist http://url4.eu/muj8
Is Spironolactone The Only Option for Women Over 35 With Acne ... http://tinyurl.com/y8mjpt4
careforskin (Care For Your Skin) Thu, 19 Nov 2009 09:47:14 -0000
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HealAllDiseases (Madison Cavanaugh) Thu, 19 Nov 2009 07:23:04 -0000
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cherrybocks (Cherry Stinson) Thu, 19 Nov 2009 06:51:08 -0000
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