Sirolimus is a relatively new immunosuppressant drug used to prevent rejection in organ transplantation, and is especially useful in kidney transplants. It is also known as rapamycin. Sirolimus is a macrolide antibiotic ("-mycin") first discovered as a product of the bacterium Streptomyces hygroscopicus in a soil sample from an island called Rapa Nui, better known as Easter Island. It is marketed as Rapamune® by Wyeth.

Interestingly, rapamycin originally was developed as an antifungal agent. However, this was abandoned when it was discovered that rapamycin had potent immunosuppressive and antiproliferative properties.

Mechanism of action

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sirolimus in treating ppl w/ neurofibromatosis type 1 & plexi4m neurofibromas tht cant b removed by surgery http://bit.ly/8Kszvl
_clinical_trial (Clinical Trials) Fri, 25 Dec 2009 06:58:39 -0000
sirolimus in treating ppl w/ neurofibromatosis type 1 & plexi4m neurofibromas tht cant b removed by surgery http://bit.ly/8Kszvl
sirolimus in treating ppl w/ neurofibromatosis type 1 & plexi4m neurofibromas tht cant b removed by surgery http://bit.ly/8Kszvl
ustrials (US Trials) Fri, 25 Dec 2009 06:58:37 -0000
sirolimus in treating ppl w/ neurofibromatosis type 1 & plexi4m neurofibromas tht cant b removed by surgery http://bit.ly/8Kszvl
sirolimus in treating ppl w/ neurofibromatosis type 1 & plexi4m neurofibromas tht cant b removed by surgery http://bit.ly/8Kszvl
newtrials_ (New Clinical Trials) Fri, 25 Dec 2009 06:58:35 -0000
sirolimus in treating ppl w/ neurofibromatosis type 1 & plexi4m neurofibromas tht cant b removed by surgery http://bit.ly/8Kszvl
sirolimus in treating ppl w/ neurofibromatosis type 1 & plexi4m neurofibromas tht cant b removed by surgery http://bit.ly/8Kszvl
goclinicaltrial (Clinical Trials) Fri, 25 Dec 2009 06:58:31 -0000
sirolimus in treating ppl w/ neurofibromatosis type 1 & plexi4m neurofibromas tht cant b removed by surgery http://bit.ly/8Kszvl
Progression of Late Stent Malapposition Beyond 2 Years After Sirolimus-Eluting Stent Implantation http://kele.es/qsa
Sciencia (Webmaster Sciencia) Thu, 24 Dec 2009 09:31:16 -0000
Progression of Late Stent Malapposition Beyond 2 Years After Sirolimus-Eluting Stent Implantation http://kele.es/qsa
［循環器トライアルデータベース］J-Cypher Registry■日本の登録研究■非保護左主幹部病変へのsirolimus溶出ステントの3年後の予後は保護病疫と変わらず，分岐部本幹と側枝への2ステントは本幹のみへのステントより予後不良：http://bit.ly/4R57r0
EBM_Library (ライフサイエンス出版) Thu, 24 Dec 2009 07:18:45 -0000
［循環器トライアルデータベース］J-Cypher Registry■日本の登録研究■非保護左主幹部病変へのsirolimus溶出ステントの3年後の予後は保護病疫と変わらず，分岐部本幹と側枝への2ステントは本幹のみへのステントより予後不良：http://bit.ly/4R57r0

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