Sirolimus is a relatively new immunosuppressant drug used to prevent rejection in organ transplantation, and is especially useful in kidney transplants. It is also known as rapamycin. Sirolimus is a macrolide antibiotic ("-mycin") first discovered as a product of the bacterium Streptomyces hygroscopicus in a soil sample from an island called Rapa Nui, better known as Easter Island. It is marketed as Rapamune® by Wyeth.

Interestingly, rapamycin originally was developed as an antifungal agent. However, this was abandoned when it was discovered that rapamycin had potent immunosuppressive and antiproliferative properties.

Mechanism of action

---

More on [ Sirolimus ]

Sirolimus - Twitter Search

Learning about Rapamycin from Pileggi @DRI_Foundation: http://en.wikipedia.org/wiki/Sirolimus #dri20
askmanny (Manny Hernandez) Sat, 07 Nov 2009 15:41:01 -0000
Learning about Rapamycin from Pileggi @DRI_Foundation: http://en.wikipedia.org/wiki/Sirolimus #dri20
ZEST:Sirolimus stents have lower restenosis rates 8 mos post acute MI http://bit.ly/2qyjiV
hartdoctor (Stephen L. Sigal) Fri, 06 Nov 2009 18:29:10 -0000
ZEST:Sirolimus stents have lower restenosis rates 8 mos post acute MI http://bit.ly/2qyjiV
Cardio: Comparison of the Efficacy and Safety of Zotarolimus-, Sirolimus-, and Paclitaxel-Eluting Stents in Patients Wit http://url4.eu/hjD3
MDLinx (Sandeep Pulim MD) Fri, 06 Nov 2009 09:10:14 -0000
Cardio: Comparison of the Efficacy and Safety of Zotarolimus-, Sirolimus-, and Paclitaxel-Eluting Stents in Patients Wit http://url4.eu/hjD3
Posted #stroke updt Coronary stenting with the sirolimus-eluting stent in .. http://bit.ly/1Qtwzt asktheneurologist
NeuroTweeter (NeuroTweeter) Tue, 03 Nov 2009 22:46:05 -0000
Posted #stroke updt Coronary stenting with the sirolimus-eluting stent in .. http://bit.ly/1Qtwzt asktheneurologist
Patients switched to sirolimus had a significantly lower rate of new skin cancers. http://bit.ly/PxqdX
cancer_aware (Amy R.) Mon, 02 Nov 2009 12:48:52 -0000
Patients switched to sirolimus had a significantly lower rate of new skin cancers. http://bit.ly/PxqdX
Switching Immunosuppressants May Reduce Cancer Risk in Kidney Transplant Recipients: Switching to sirolimus (SR.. http://bit.ly/3iVBmS
renalandurology (Renal Urology News) Sun, 01 Nov 2009 02:38:49 -0000
Switching Immunosuppressants May Reduce Cancer Risk in Kidney Transplant Recipients: Switching to sirolimus (SR.. http://bit.ly/3iVBmS

Subscribe to Sirolimus RSS feed