Sirolimus is a relatively new immunosuppressant drug used to prevent rejection in organ transplantation, and is especially useful in kidney transplants. It is also known as rapamycin. Sirolimus is a macrolide antibiotic ("-mycin") first discovered as a product of the bacterium Streptomyces hygroscopicus in a soil sample from an island called Rapa Nui, better known as Easter Island. It is marketed as Rapamune® by Wyeth.

Interestingly, rapamycin originally was developed as an antifungal agent. However, this was abandoned when it was discovered that rapamycin had potent immunosuppressive and antiproliferative properties.

Mechanism of action

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Risk of tuberculosis infection in psoriasis patients treated with anti-TNF therapy #biologics #TB prior #LTBI screening http://t.co/glgk8I7L
AnnemarieVtW (A. Vroom-ten Wolde) Wed, 25 Jan 2012 09:04:56 -0000
Risk of tuberculosis infection in psoriasis patients treated with anti-TNF therapy #biologics #TB prior #LTBI screening http://t.co/glgk8I7L
Prior knowledge of _HPV_ status improves detection of CIN2+ by cytology screening. Safety of clopidogrel being... http://t.co/RrVloxjd
Olenehem (Olene Forte) Wed, 25 Jan 2012 04:43:36 -0000
Prior knowledge of _HPV_ status improves detection of CIN2+ by cytology screening. Safety of clopidogrel being... http://t.co/RrVloxjd
Comparison of Vascular Remodeling in Patients Treated With Sirolimus-Versus Zotarolimus-Eluting Stent Following Acut... http://t.co/4uJv5vpL
gladeolie (dreammerchant) Wed, 25 Jan 2012 04:12:39 -0000
Comparison of Vascular Remodeling in Patients Treated With Sirolimus-Versus Zotarolimus-Eluting Stent Following Acut... http://t.co/4uJv5vpL
RT @SympoCardiology: 5year follow-up of Endeavor DES System Vs the Cypher Sirolimus-Eluting Cor. Stent System in De Novo Native CA Lesions http://t.co/krNcF9Eu
Health_In (Health In) Tue, 24 Jan 2012 12:24:40 -0000
RT @SympoCardiology: 5year follow-up of Endeavor DES System Vs the Cypher Sirolimus-Eluting Cor. Stent System in De Novo Native CA Lesions http://t.co/krNcF9Eu
5year follow-up of Endeavor DES System Vs the Cypher Sirolimus-Eluting Cor. Stent System in De Novo Native CA Lesions http://t.co/krNcF9Eu
SympoCardiology (Symposier Cardiology) Tue, 24 Jan 2012 12:13:07 -0000
5year follow-up of Endeavor DES System Vs the Cypher Sirolimus-Eluting Cor. Stent System in De Novo Native CA Lesions http://t.co/krNcF9Eu
Anyone have experience with sirolimus-eluting stents to address in-stent restenosis? - From Reuters Health/TDC http://t.co/6Paaezog #health
docchannelnews (The Doctor's Channel) Mon, 23 Jan 2012 22:51:30 -0000
Anyone have experience with sirolimus-eluting stents to address in-stent restenosis? - From Reuters Health/TDC http://t.co/6Paaezog #health

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