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Simvastatin (INN) (IPA: ) is a hypolipidemic drug belonging to the class of pharmaceuticals called "statins". It is used to control hypercholesterolemia (elevated cholesterol levels) and to prevent cardiovascular disease. Simvastatin is a synthetic derivate of a fermentation product of Aspergillus terreus.
History
The development of simvastatin was closely linked with the research and development of lovastatin. Biochemist Jesse Huff and his colleagues at Merck began researching the biosynthesis of cholesterol in the early 1950s. In 1956, mevalonic acid was isolated from a yeast extract by Karl Folkers, Carl Hoffman, and others at Merck; while Huff and his associates confirmed that mevalonic acid was an intermediate in cholesterol biosynthesis. In 1959, the HMG-CoA reductase enzyme (a major contributor of internal cholesterol production) was discovered by researchers at the Max Planck Institute. This discovery encouraged scientists worldwide to find an effective inhibitor of this enzyme.
By 1976, Akira Endo had isolated the first inhibitor (compactin) from yeast cultures in Sankyo, Japan. In 1979, Hoffman and colleagues isolated lovastatin from a strain of the fungus Aspergillus terreus. While developing and researching lovastatin, Merck scientists synthetically derived a more potent HMG-CoA reductase inhibitor from a fermentation product of Aspergillus terreus, which was designated MK-733 (later to be named simvastatin)http://www-personal.umich.edu/~afuah/cases/case10.html .
More on [ Simvastatin ]
Lipid Lowering Agents :: Drugs and Medications
Vytorin Settlement: Vytorin Settlement(Ezetimibe/Simvastatin): Resources and information at vytorinsettlement.com http://bit.ly/46Rfiv
mysitefeed (mysitefeed) Sat, 07 Nov 2009 04:02:32 -0000
Vytorin Settlement: Vytorin Settlement(Ezetimibe/Simvastatin): Resources and information at vytorinsettlement.com http://bit.ly/46Rfiv
Vytorin Settlement: Vytorin Settlement(Ezetimibe/Simvastatin): Resources and information at vytorinsettlement.com http://bit.ly/3Cikjd
mysitefeed (mysitefeed) Sat, 07 Nov 2009 03:02:30 -0000
Vytorin Settlement: Vytorin Settlement(Ezetimibe/Simvastatin): Resources and information at vytorinsettlement.com http://bit.ly/3Cikjd
Cholesterol drug sales set to double: An official from an Indian drugmaker, which makes generic simvastatin, (o.. http://bit.ly/17jbY0
MedicalNewsUSA (Medical News) Fri, 06 Nov 2009 22:23:39 -0000
Cholesterol drug sales set to double: An official from an Indian drugmaker, which makes generic simvastatin, (o.. http://bit.ly/17jbY0
Generics Makers Line Up To Sell Copies Of Pfizer's Lipitor: ... drugs such as simvastatin. Separately, Pfiz.. http://bit.ly/38mu8t
MedicalNewsUSA (Medical News) Fri, 06 Nov 2009 15:05:45 -0000
Generics Makers Line Up To Sell Copies Of Pfizer's Lipitor: ... drugs such as simvastatin. Separately, Pfiz.. http://bit.ly/38mu8t
EDS: Ezetimibe/simvastatin: Expert Opinion on Drug Safety , November 2009, Vol. 8, No. 6, Pages 715-725. http://bit.ly/4ukGJS
ExpertOpinion (Expert Opinion) Fri, 06 Nov 2009 13:37:28 -0000
EDS: Ezetimibe/simvastatin: Expert Opinion on Drug Safety , November 2009, Vol. 8, No. 6, Pages 715-725. http://bit.ly/4ukGJS
Patients treated with carnitine and simvastatin showed a reduction in small-sized LDL proportion and an increase in LDL particle size #FB
mrcmv (charles varner) Thu, 05 Nov 2009 23:26:19 -0000
Patients treated with carnitine and simvastatin showed a reduction in small-sized LDL proportion and an increase in LDL particle size #FB
DrugDigest: Simvastatin (Zocor) - Information on dosage, usage, side effects, interactions, and drug comparisons, including generics when available.
eMedicine Health: Simvastatin (Zocor) - Provides patient medication information and resources.
Meta Description: [ Zocor is the brand name. Simvastatin is the generic name. Zocor is the first drug shown to reduce the total death rate by reducing LDL ( ]
Zocor (Simvastatin) - Patient information including contraindications, side effects, warnings and precautions.
Zocor.com - Educate consumers and healthcare professionals about high cholesterol and treatment options available. Includes information about cholesterol, including a discussion of its causes, ways to reduce high cholesterol, and a quiz designed to help people determine if they're at risk for a heart attack.
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