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Simvastatin (INN) (IPA: ) is a hypolipidemic drug belonging to the class of pharmaceuticals called "statins". It is used to control hypercholesterolemia (elevated cholesterol levels) and to prevent cardiovascular disease. Simvastatin is a synthetic derivate of a fermentation product of Aspergillus terreus.
History
The development of simvastatin was closely linked with the research and development of lovastatin. Biochemist Jesse Huff and his colleagues at Merck began researching the biosynthesis of cholesterol in the early 1950s. In 1956, mevalonic acid was isolated from a yeast extract by Karl Folkers, Carl Hoffman, and others at Merck; while Huff and his associates confirmed that mevalonic acid was an intermediate in cholesterol biosynthesis. In 1959, the HMG-CoA reductase enzyme (a major contributor of internal cholesterol production) was discovered by researchers at the Max Planck Institute. This discovery encouraged scientists worldwide to find an effective inhibitor of this enzyme.
By 1976, Akira Endo had isolated the first inhibitor (compactin) from yeast cultures in Sankyo, Japan. In 1979, Hoffman and colleagues isolated lovastatin from a strain of the fungus Aspergillus terreus. While developing and researching lovastatin, Merck scientists synthetically derived a more potent HMG-CoA reductase inhibitor from a fermentation product of Aspergillus terreus, which was designated MK-733 (later to be named simvastatin)http://www-personal.umich.edu/~afuah/cases/case10.html .
More on [ Simvastatin ]
Lipid Lowering Agents :: Drugs and Medications
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DrugDigest: Simvastatin (Zocor) - Information on dosage, usage, side effects, interactions, and drug comparisons, including generics when available.
eMedicine Health: Simvastatin (Zocor) - Provides patient medication information and resources.
Meta Description: [ Zocor is the brand name. Simvastatin is the generic name. Zocor is the first drug shown to reduce the total death rate by reducing LDL ( ]
Zocor (Simvastatin) - Patient information including contraindications, side effects, warnings and precautions.
Zocor.com - Educate consumers and healthcare professionals about high cholesterol and treatment options available. Includes information about cholesterol, including a discussion of its causes, ways to reduce high cholesterol, and a quiz designed to help people determine if they're at risk for a heart attack.
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