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Sildenafil citrate, sold under the names Viagra, Revatio and generically under various other names, is a drug used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH), developed by the pharmaceutical company Pfizer. Viagra pills are blue and diamond-shaped with the words "Pfizer" on one side and "VGR xx" (with xx representing 25, 50 or 100, the dose of that pill in milligrams) on the other. Its primary competitors on the market are tadalafil (Cialis), and vardenafil (Levitra).
History
Sildenafil (compound UK-92,480) was synthesized by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent research facility. It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a form of ischaemic cardiovascular disease). Phase I clinical trials under the direction of Ian Osterloh suggested that the drug had little effect on angina, but that it could induce marked penile erections Terrett, N. K. et al. Sildenafil (Viagra), a potent and selective inhibitor of Type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction. Bioorg. Med. Chem. Lett. 1996, 6, 1819-1824. . Pfizer therefore decided to market it for erectile dysfunction, rather than for angina. The drug was patented in 1996, approved for use in erectile dysfunction by the Food and Drug Administration on March 27, 1998, becoming the first pill approved to treat erectile dysfunction in the United States, and offered for sale in the United States later that year Kling J. From hypertension to angina to Viagra. Mod Drug Discov 1998;1:31-38. Fulltext. . It soon became a great success: annual sales of Viagra in the period 1999–2001 exceeded $1 billion.
The British press portrayed Peter Dunn and Albert Wood as the inventors of the drug, a claim which Pfizer disputes.Bellis, Mary. "Viagra, the patenting of an aphrodisiac." About.com.. Their names are on the manufacturing patent application drug, but Pfizer claims this is only for convenience.
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Viagra - Pfizer's official site for this drug, with information for both patients and medical professionals.
Meta Description: [ Pfizer Official VIAGRA Web Site for erectile dysfunction, impotence, and sexual health information. ]
American Academy of Family Physicians - Using Viagra - A look at what this drug is, as well as erectile dysfuction, the side affects and who should not take it.
FDA Adds More Cautions to Viagra Labelling. - Abstracted from: FDA Talk Paper
FDA Viagra Product Information - FDA consumer source for information about Viagra, the medication used to treat men's impotence
Meta Description: [ Viagra (sildenafil citrate) Information ]
Postmarketing Safety of Sildenafil Citrate (Viagra) - FDA summary of reports of death in users, as received from marketing March - November, 1998.
Safety and Efficacy of Sildenafil in Postmenopausal Women with Sexual Dysfunction - Abstract of a peer-reviewed study on the effectiveness of Viagra for women.
Sildenafil - FamilyDoctor.org - Information for Consumers in English or Spanish.
The Viagra Prank - Comedy article journaling the author's online Viagra purchase and the aftereffects of taking it.
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Viagra - Information, including updated labeling, new prescribing information, safety updates, consumer information, and the clinical review of the studies. FDA/Centre for Drug Evaluation and Research.
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Viagra Consumer Information - FDA consumer information page about Viagra, the medication used to treat men's impotence.
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Viagra Drug Interactions - A partial list of drugs which should not be taken in conjunction with Viagra.
Viagra Fans - Information Exchange - Discussion forum relating to Viagra, Cialis and Levitra.
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Viagra Frequently Asked Questions - A list of questions and answers on Viagra has been developed by CDER's Drug Information Branch.
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