Sevoflurane (2,2,2-trifluoro-1-(trifluoromethyl) ethyl ether), also called fluoromethyl, is a sweet-smelling, non-flammable fully-fluorinated methyl isopropyl ether, used for induction and maintenance of general anesthesia. Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiology. It is often administered in a mixture of nitrous oxide and oxygen. After desflurane it is the volatile anesthetic with the fastest onset and offset.

Though it vaporizes readily, it is a liquid at room temperature and is administered via a anesthetic vaporizer attached to an anesthetic machine.

It was introduced into clinical practice initially in Japan in 1990.

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