submit urlsubmit rss feedadd directoryphysician directoryPharmacology employment

article

Selegiline (l-deprenyl, Eldepryl® or Anipryl® *) is a drug used for the treatment of early-stage Parkinson's disease and senile dementia. In normal clinical doses it is a selective MAO-B inhibitor, however in very large doses (>25 mg in a typical adult) it loses its specificity and also inhibits MAO-A. Since it is selective for MAO-B, no special dietary restrictions are needed as with other MAOI drugs. The drug was researched by Joseph Knoll.

Uses


It is sometimes used off-label to treat narcolepsy and as a nootropic, as well as for its purported life-extending effects. It is also reported to positively affect libido, particularly in older males. As of February 28, 2006, Selegiline has also been approved by the Food and Drug Administration (FDA) to treat major depression using a transdermal patch (Emsam Patch). Selegiline is also used (at extremely high dosages relative to humans) in veterinary medicine to treat the symptoms of Cushing's disease and so-called "cognitive dysfunction" in dogs. As of June 26, 2006, a Selegiline transdermal patch is being tested for its effectiveness in treating ADHD (Source:Pharma.org).

Mechanism of Action


Selegiline raises dopamine and phenylethylamine levels in the CNS without directly affecting serotonin or norepinephrine. It does so because of its mentioned selectivity versus MAO-B. Selegiline can indirectly raise norepinephrine because dopamine can be catabolized within the brain to norepinephrine, although the extent of this is variable. Selegiline is partly metabolized to an inactive stereoisomer of methamphetamine in vivo in levels that, even if active, most likely are far too low to have any significant effect. However, due to this selegiline can cause false positives for amphetamine/methamphetamine on drug tests.

More on [ Selegiline ]


directory of related categories

 
Selegiline RSS feed
CFDA: FDA Latest Computer Systems Warning Letters

WL Issued to Amrex Zetron Inc
FDA Tue, 14 Apr 2009 00:00:00 -0400
FDA Warning Letter Issued to Amrex Zetron Inc on 14 Apr 2009 by Los Angeles District Office
WL Issued to Coast Institutional Review Board
FDA Tue, 14 Apr 2009 00:00:00 -0400
FDA Warning Letter Issued to Coast Institutional Review Board on 14 Apr 2009 by Center for Drug Evaluation and Research
WL Issued to Branitz, Bruce, MD
FDA Thu, 09 Apr 2009 00:00:00 -0400
FDA Warning Letter Issued to Branitz, Bruce, MD on 09 Apr 2009 by Center for Drug Evaluation and Research
WL Issued to Cote, Charles J., MD
FDA Mon, 02 Mar 2009 00:00:00 -0400
FDA Warning Letter Issued to Cote, Charles J., MD on 02 Mar 2009 by Center for Drug Evaluation and Research
WL Issued to Genzyme Corporation
FDA Fri, 27 Feb 2009 00:00:00 -0400
FDA Warning Letter Issued to Genzyme Corporation on 27 Feb 2009 by New England District Office
WL Issued to Hammill Manufacturing Company
FDA Tue, 06 Jan 2009 00:00:00 -0400
FDA Warning Letter Issued to Hammill Manufacturing Company on 06 Jan 2009 by Cincinnati District Office

CFDA: FDA Latest Drug GCP Warning Letters

WL Issued to Coast Institutional Review Board
FDA Tue, 14 Apr 2009 00:00:00 -0400
FDA Warning Letter Issued to Coast Institutional Review Board on 14 Apr 2009 by Center for Drug Evaluation and Research
WL Issued to Branitz, Bruce, MD
FDA Thu, 09 Apr 2009 00:00:00 -0400
FDA Warning Letter Issued to Branitz, Bruce, MD on 09 Apr 2009 by Center for Drug Evaluation and Research
WL Issued to Bukowski, Ronald M, MD
FDA Mon, 30 Mar 2009 00:00:00 -0400
FDA Warning Letter Issued to Bukowski, Ronald M, MD on 30 Mar 2009 by Center for Drug Evaluation and Research
WL Issued to Youabian, Inc
FDA Tue, 17 Mar 2009 00:00:00 -0400
FDA Warning Letter Issued to Youabian, Inc on 17 Mar 2009 by Los Angeles District Office
WL Issued to Provena St. Joseph's Medical Center IRB
FDA Thu, 12 Mar 2009 00:00:00 -0400
FDA Warning Letter Issued to Provena St. Joseph's Medical Center IRB on 12 Mar 2009 by Center for Biologics Evaluation and Research
WL Issued to Paulson, Daniel M., MD
FDA Wed, 11 Mar 2009 00:00:00 -0400
FDA Warning Letter Issued to Paulson, Daniel M., MD on 11 Mar 2009 by Center for Drug Evaluation and Research

 
Subscribe to Drugs_and_Medications RSS feed

directory of related sites

Selegiline [l-deprenyl] - Describes this medication as a mood-brightener.

Selegine HCl Oral - Patient handout, with links to more technical information on pharmacology, drug interactions, and other topics. [Requires free registration.]

Selegiline related videos
Drug Name Confusion: Salagen and Selegiline (Feb 2006)
Next Video
Selegiline related videos

 

HOMEADVERTISINGABOUT US

articlesartsbusinesscomputersgameshealthhospitalshomekids & teensnewsmobilephysiciansrecreationreferenceregionalscienceshoppingsocietysportsworld


Submit a Site About Become an Editor