Gourt > Health > Pharmacy > Drugs and Medications > R > Rosiglitazone (1)
Rosiglitazone is an anti-diabetic drug from the thiazolidinedione class. It is being marketed as Avandia® by the pharmaceutical company GlaxoSmithKline, both as a standalone preparation and in combination with metformin (Avandamet®). Another combination drug approved by the FDA is Avandaryl® (with glimepiride).
Like other thiazolidinediones, its mechanism of action is by activation of the intracellular receptor class of the peroxisome proliferator-activated receptors (PPARs), specifically PPARγ. Rosiglitazone is a pure ligand of PPARγ, and has no PPARα-binding action. Apart from its effect on insulin resistance, it appears to have an anti-inflammatory effect: nuclear factor kappa-B (NFκB) levels fall and inhibitor (IκB) levels increase in patients on rosiglitazone (Mohanty et al).
References
- Mohanty P, Aljada A, Ghanim H, Hofmeyer D, Tripathy D, Syed T, al-Haddad W, Dhindsa S, Dandona P. Evidence for a potent antiinflammatory effect of rosiglitazone. J Clin Endocrinol Metab 2004; 89:2728-35.
Antihyperglycaemics: prescribing rate unchanged by rosiglitazone warning http://kele.es/omG
Sciencia (Webmaster Sciencia) Sun, 13 Dec 2009 13:00:48 -0000
Antihyperglycaemics: prescribing rate unchanged by rosiglitazone warning http://kele.es/omG
RT @tweetmeme Générique Avandia (Rosiglitazone 2/4mg) â¬0.30 Par comprimé - Diabète @ BEST ONLINE PHARMACY http://bit.ly/5WrYgi
Nemoguschiy (ÐмиÑÑий ÐемогÑÑий) Sat, 12 Dec 2009 17:58:14 -0000
RT @tweetmeme Générique Avandia (Rosiglitazone 2/4mg) €0.30 Par comprimé - Diabète @ BEST ONLINE PHARMACY http://bit.ly/5WrYgi
rosiglitazone in treating ppl w/ pituitary tumors http://bit.ly/8cPixB
localtrials (US Clinical Trials ) Thu, 10 Dec 2009 19:22:57 -0000
rosiglitazone in treating ppl w/ pituitary tumors http://bit.ly/8cPixB
rosiglitazone in treating ppl w/ pituitary tumors http://bit.ly/8cPixB
usclinicaltrial (US Clinical Trials) Thu, 10 Dec 2009 19:14:57 -0000
rosiglitazone in treating ppl w/ pituitary tumors http://bit.ly/8cPixB
rosiglitazone in treating ppl w/ pituitary tumors http://bit.ly/8cPixB
recruitingtrial (Recruiting Trials) Thu, 10 Dec 2009 17:38:51 -0000
rosiglitazone in treating ppl w/ pituitary tumors http://bit.ly/8cPixB
rosiglitazone in treating ppl w/ newly diagnosed acth-secreting pituitary tumor http://bit.ly/4phR7K
localtrials (US Clinical Trials ) Thu, 10 Dec 2009 14:06:52 -0000
rosiglitazone in treating ppl w/ newly diagnosed acth-secreting pituitary tumor http://bit.ly/4phR7K
Avandia - GlaxoSmithKline - Official product site with information primarily intended for diabetics. Includes free membership area.
Meta Description: [ Find information on the diabetes medication Avandia, as well as managing type 2 diabetes. ]
Avandia Consumer Information - FDA - Patient FAQ in html format with a link to approved labeling (as pdf).
DrugDigest: Rosiglitazone ( Avandia ) - Information on dosage, usage, side effects, interactions, and drug comparisons, including generics when available.
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