Riluzole is a drug used to treat amyotrophic lateral sclerosis. It delays the onset of ventilator-dependence or tracheostomy in selected patients and may increase survival by approximately two months.

It is marketed by Aventis Pharmaceuticals Inc with the brand name Rilutek.

Mechanism of action

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Riluzole has several actions:

• Sodium channel blockade
• High-voltage calcium channel blockade
• N-methyl-D-aspartate (NMDA)/glutamate receptor blockade

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