.png | CAS_number = 132875-61-7 | ATC_prefix = N01 | ATC_suffix = AH06 | ATC_supplemental = | PubChem = 60815 | DrugBank = APRD01216 | chemical_formula = C₂₀H₂₈N₂O₅ | molecular_weight = 376.447 g/mol | smiles = | melting_point = 5 | bioavailability = | protein_bound = 70% (bound to plasma proteins) | metabolism = | elimination_half-life = 1-20 minutes | pregnancy_category = | legal_status = | routes_of_administration = }} Remifentanil is a potent ultra short-acting synthetic opioid analgesic drug. It is given to patients during surgery to relieve pain and as an adjunct to an anaesthetic. Remifentanil is used for sedation as well as combined with other medications for use in general anesthesia.

Dosing

---

It is administered in the form remifentanil hydrochloride and in adults is given as an intravenous infusion in doses ranging from 0.1 microgram per kilogram per minute to 0.5 (µg/kg)/min. Children may require higher infusion rates (up to 1.0 (µg/kg)/min). Doses listed in the package insert from its manufacturer are much higher than those used in actual clinical practice. The clinically useful infusion rates are 0.025-0.1 (µg/kg)/min for sedation (rates adjusted to age of patient, severity of their illness and invasiveness of surgical procedure). Small amounts of other sedative medication are given along with the remifentanil to produce sedation. Clinically useful infusion rates in general anesthesia are similar to those used for sedation, except other potent medications are utilized along with the Remifentanil in the case of general anesthesia.

Metabolism

---

Unlike other synthetic opioids, its clearance is dependent on non-specific plasma esterases. This means that accumulation does not occur with remifentanil and its context-sensitive half-life remains at 4 minutes after a 4 hour infusion.

More on [ Remifentanil ]

Remifentanil - Twitter Search

Postoperative opioid usage in children receiving Remifentanil vs. sufentanil http://bit.ly/5qecD7
acetavance (acetavance) Sat, 28 Nov 2009 17:18:01 -0000
Postoperative opioid usage in children receiving Remifentanil vs. sufentanil http://bit.ly/5qecD7
Effect of remifentanil on intracranial pressure and cerebral blood flow velocity in patien.. http://bit.ly/6vuAxA http://sciencia.org/
Sciencia (Webmaster Sciencia) Thu, 26 Nov 2009 18:34:29 -0000
Effect of remifentanil on intracranial pressure and cerebral blood flow velocity in patien.. http://bit.ly/6vuAxA http://sciencia.org/

Subscribe to Remifentanil RSS feed