.png | CAS_number = 132875-61-7 | ATC_prefix = N01 | ATC_suffix = AH06 | ATC_supplemental = | PubChem = 60815 | DrugBank = APRD01216 | chemical_formula = C₂₀H₂₈N₂O₅ | molecular_weight = 376.447 g/mol | smiles = | melting_point = 5 | bioavailability = | protein_bound = 70% (bound to plasma proteins) | metabolism = | elimination_half-life = 1-20 minutes | pregnancy_category = | legal_status = | routes_of_administration = }} Remifentanil is a potent ultra short-acting synthetic opioid analgesic drug. It is given to patients during surgery to relieve pain and as an adjunct to an anaesthetic. Remifentanil is used for sedation as well as combined with other medications for use in general anesthesia.

Dosing

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It is administered in the form remifentanil hydrochloride and in adults is given as an intravenous infusion in doses ranging from 0.1 microgram per kilogram per minute to 0.5 (µg/kg)/min. Children may require higher infusion rates (up to 1.0 (µg/kg)/min). Doses listed in the package insert from its manufacturer are much higher than those used in actual clinical practice. The clinically useful infusion rates are 0.025-0.1 (µg/kg)/min for sedation (rates adjusted to age of patient, severity of their illness and invasiveness of surgical procedure). Small amounts of other sedative medication are given along with the remifentanil to produce sedation. Clinically useful infusion rates in general anesthesia are similar to those used for sedation, except other potent medications are utilized along with the Remifentanil in the case of general anesthesia.

Metabolism

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Unlike other synthetic opioids, its clearance is dependent on non-specific plasma esterases. This means that accumulation does not occur with remifentanil and its context-sensitive half-life remains at 4 minutes after a 4 hour infusion.

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Practical use of remifentanil for pediatric patients.: Practical use of remifentanil for pediatric patients.... http://t.co/9g8FuWuK
AnestesiaF (Anestesia-Fabumed) Fri, 03 Feb 2012 09:13:17 -0000
Practical use of remifentanil for pediatric patients.: Practical use of remifentanil for pediatric patients.... http://t.co/9g8FuWuK
"Feasibility of Closed-loop Titration of Propofol and Remifentanil Guided by the Spectral M-Entropy..." http://t.co/4cdCWETD
medicalyoshi (@1962yoshi) Fri, 03 Feb 2012 00:31:38 -0000
"Feasibility of Closed-loop Titration of Propofol and Remifentanil Guided by the Spectral M-Entropy..." http://t.co/4cdCWETD
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