Quinine, is a natural white crystalline alkaloid having antipyretic, anti-malarial with analgesic and anti-inflammatory properties and a bitter taste. It is a stereoisomer of quinidine.

Quinine was previously superseded by chloroquine, but is now again the drug of choice for treatment of falciparum malaria because of the rise of chloroquine resistance. Quinine is available with a prescription in the U.S.. Quinine is also used to treat nocturnal leg cramps and arthritis and it has also been used (with limited success) to treat people who had been infected by prions. It was once a popular heroin adulterant.

Mechanism of action

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The theorized mechanism of action for quinine and related anti-malarial drugs is that these drugs are toxic to the malaria parasite, specifically by interfering with the parasite's ability to break down and digest hemoglobin, thus starving the parasite and/or causing the build-up of toxic levels of partially degraded hemoglobin in the parasite.

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