Quetiapine (pronounced kwe-TYE-a-peen or kwəˈtɑɪəˌpiːn), marketed by AstraZeneca with the brand name Seroquel, belongs to a series of neuroleptics known as "atypical antipsychotics", which have, over the last four decades, become increasingly popular alternatives to "typical antipsychotics", such as haloperidol (Haldol).

Uses

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Quetiapine has Food and Drug Administration (FDA) and international approvals for the treatment of schizophrenia and acute mania in bipolar disorder. It is also used off-label to treat other disorders, such as post-traumatic stress disorder, alcoholism, obsessive compulsive disorder, anxiety disorders, hallucinations in Parkinson's disease patients using ropinirole, and as a sedative for those with sleep disorders. It has also shown to be effective as monotherapeutic treatment of depressive episodes associated with bipolar depression, for which AstraZeneca is currently seeking FDA approval. ^*

Chemistry

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Quetiapine (shown in figure) is 11-^*-1-piperazinyl]dibenzo^**thiazepine," target="_blank" >C₂₁H₂₅N₃O₂S. Dosages are based on milligrams of this base. The Seroquel formulation is as a fumarate salt with the chemical formula C₄₂H₅0N₆O₄S₂·C₄H₄O₄ and systematic name 2-^*thiazepin-11-yl-1-piperazinyl)ethoxy]-ethanol fumarate (2:1) (salt).

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