Gourt > Health > Pharmacy > Drugs and Medications > P > Pyrimethamine
Pyrimethamine (Daraprim®) is a medication used for protozoal infections. It is commonly used as an antimalarial drug (for both treatment and prevention), and is also used in the treatment of Toxoplasma gondii infections in immunocompromised patients, such as HIV-positive individuals.
Mechanism of action
Pyrimethamine interferes with folic acid synthesis by inhibiting the enzyme dihydrofolate reductase. Folic acid is needed for DNA and RNA synthesis in many species, including protozoa.
Mechanism of resistance
Resistance to pyrimethamine is widespread. Mutations in the gene for dihydrofolate reductase may reduce the effectiveness of pyrimethamine (PMID 15155209). These mutations decrease the binding affinity between pyrimethamine and dihydrofolate reductase by steric interactions (PMID 14711307). More on [ Pyrimethamine ]
Science News Randomized Trial of Piperaquine with Sulfadoxine-Pyrimethamine or Dihydroartemisinin f.. http://bit.ly/lStyb
sciencestage (ScienceStage) Mon, 02 Nov 2009 00:03:08 -0000
Science News Randomized Trial of Piperaquine with Sulfadoxine-Pyrimethamine or Dihydroartemisinin f.. http://bit.ly/lStyb
intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis http://bit.ly/2HjLq1
CharlieNeck (Carlos Cuello) Fri, 30 Oct 2009 17:11:46 -0000
intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis http://bit.ly/2HjLq1
Daraprim - About Pyrimethamine.
Daraprim - Product information for US residents in PDF format. [Acrobat Reader required]
DrugDigest: Pyrimethamine ( Daraprim ) - Information on dosage, usage, side effects, interactions, and drug comparisons, including generics when available.
Pyrimethamine - Used for the treatment and prevention of malaria. Also used to treat AIDS-related diarrhea and as one of a combination of drugs to treat Toxoplasma gondii, a protozoal infection. Marketed as Daraprim and Fansidar. Site includes drug description, dosage, and side effects.
| The 13-metal medal - Periodic Table of Videos | |
| Next Video | |