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Pseudoephedrine is a sympathomimetic amine commonly used as a decongestant. The salts pseudoephedrine hydrochloride and pseudoephedrine sulfate are found in many over-the-counter preparations either as single-ingredient preparations, or more commonly in combination with antihistamines, paracetamol and/or ibuprofen. It is often referred to by consumers as Sudafed, which is the trademark for a common brand of pseudoephedrine hydrochloride.
Unlike antihistamines, which modify the systemic histamine-mediated allergic response, pseudoephedrine only relieves nasal congestion commonly associated with colds or allergies. The advantage of oral pseudoephedrine over topical nasal preparations, such as oxymetazoline, is that it does not cause rebound congestion (rhinitis medicamentosa); however, it is more likely to cause adverse effects including hypertension.
Chemistry
Pseudoephedrine is a phenethylamine, and an isomer of ephedrine. Pseudoephedrine is the International Nonproprietary Name (INN) of the (1S,2S)- diastereomer of ephedrine (which has 1R,2S- configuration). Other names are (+)-pseudoephedrine and D-pseudoephedrine. (Reynolds, 1989) The enantiomer (-)-(1R,2R)-Pseudoephedrine has fewer side-effects, fewer central nervous system (CNS) stimulatory effects, does not reduce to d-methamphetamine, and yet retains its efficacy as a decongestant. However, the patent holder for (-)-Pseudoephedrine has not yet sought or received government approval for its sale to the public. (US Patent 6,495,529) More on [ Pseudoephedrine ]
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Ephedrine and Pseudoephedrine - About these closely related drugs with actions and side effects similar to the hormone epinephrine (adrenaline). Discusses uses and interactions with foods, other drugs, herbs, and other agents.
Pseudoephedrine - MEDLINEplus drug information for this medication, relevant to brand names Afrin; Cenafed; Decofed; Dorcol; Efidac/24; Pediacare; Sinutab; and Sudafed. Includes indications, side effects, precautions, and other advice for patients.
Meta Description: [ Pseudoephedrine ]
Sudafed Decongestant - Includes product usage, directions, warnings, interactions, ingredients and FAQs.
Meta Description: [ Sudafed(r) products offer relief from cold, sinus and allergy symptoms. Learn more about our family of medicines, including new Sudafed PE(TM) ]
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