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Procarbazine (Matulane® (US), Natulan (Canada)) is an antineoplastic chemotherapy drug for the treatment of Hodgkin's lymphoma and certain brain cancers (such as Glioblastoma multiforme). It is a member of a group of medicines called alkylating agents. Its mechanism of action is not fully understood. Metabolism yields azo-procarbazine and hydrogen peroxide which results in the breaking of DNA strands.
When used to treat Hodgkin's Lymphoma, it is often delivered in a regimen known as MOPP when administrated with a Nitrogen Mustard, Vincristine (tradename Oncovin), and Prednisone (the second P being Procarbazine itself). Alternatively, when used to treat certain brain tumors (malignant gliomas), it is often dosed as PCV when combined with Lomustine (often called CCNU) and Vincristine.
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More on [ Procarbazine ]
MOPP Rx for lymphoma, Wilm's tumor & choriocarcinoma: Mechlorethamine, Oncovin (vincristine), Procarbazine, Prednisone
USMLEStepStudy (USMLEStepStudy) Sat, 28 Nov 2009 12:48:45 -0000
MOPP Rx for lymphoma, Wilm's tumor & choriocarcinoma: Mechlorethamine, Oncovin (vincristine), Procarbazine, Prednisone
Procarbazine - Used in combination with other chemotherapies to treat Hodgkin's disease. Site has drug description, list of side effects, and dosage information.
Procarbazine - FamilyDoctor.org - Information for consumers in English or Spanish.
