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Primidone, is an anticonvulsant of the pyrimidinedione class whose active metabolites, phenobarbital (minor) and phenylethylmalonamide (PEMA) (major), are also anticonvulsants. Like many anticonvulsants, it is a GABA receptor agonist (i.e., it simulates the action of GABA in the central nervous system). Primidone, especially when combined with phenytoin, was once considered the treatment of choice for temporal lobe epilepsy with tonic-clonic seizures.}} In 1990, it, along with phenobarbital, was a second-line agent in partial epilepsy with or without secondarily generalized tonic-clonic seizures and was one of four agents (the others being carbamazepine, phenytoin and phenobarbital) that was used, along with ethosuximide or a benzodiazepine for any absence or myoclonic seizures, when valproate failed to control tonic-clonics (at least in the United States).}}
By the year 2000, primidone was seen as something that "may...be useful" (again, along with phenobarbital) as an add-on to valproate, lamotrigine, or topiramate in the treatment of GTCS, provided that carbamazepine or phenytoin can't be used for some reason. | url = http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&list_uids=11096777&dopt=ExternalLink}}
It has been available as a generic drug from Lannett since 1978.
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Primidone - FamilyDoctor.org - Information for consumers in English or Spanish.
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