Prednisone is a synthetic corticosteroid drug which is usually taken orally and can be used for a large number of different conditions. It has a mainly glucocorticoid effect. Prednisone is a prodrug that is converted by the liver into prednisolone, which is the active drug and a steroid.

Uses

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Prednisone is particularly effective as an immunosuppressant and affects virtually all of the immune system. It can therefore be used in autoimmune diseases, inflammatory diseases (such as asthma, severe poison ivy, and Crohn's disease), various kidney diseases including nephrotic syndrome, and to prevent and treat rejection in organ transplantation.

History

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Prednisone was invented in the early 1950s when Arthur Nobile (1920 - 2004) at Schering demonstrated that the side effects of cortisone such as water retention, high blood pressure and muscle weakness could be removed by oxidisation of the drug through exposure to microbes. The drug was introduced by Schering in the mid-1960s.

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RT @elgipi Can Montelukast Shorten Prednisolone Therapy in Children with Mild to Moderate Acute Asthma? Pues no http://bit.ly/7neXaw
rubengp (Rubén García) Sun, 03 Jan 2010 13:36:35 -0000
RT @elgipi Can Montelukast Shorten Prednisolone Therapy in Children with Mild to Moderate Acute Asthma? Pues no http://bit.ly/7neXaw
RT @elgipi Can Montelukast Shorten Prednisolone Therapy in Children with Mild to Moderate Acute Asthma? Pues no http://bit.ly/7neXaw
Pediatria (Cristobal Buñuel) Sun, 03 Jan 2010 13:35:58 -0000
RT @elgipi Can Montelukast Shorten Prednisolone Therapy in Children with Mild to Moderate Acute Asthma? Pues no http://bit.ly/7neXaw
Can Montelukast Shorten Prednisolone Therapy in Children with Mild to Moderate Acute Asthma? Pues no http://bit.ly/7neXaw
elgipi (El gipi) Sun, 03 Jan 2010 13:24:59 -0000
Can Montelukast Shorten Prednisolone Therapy in Children with Mild to Moderate Acute Asthma? Pues no http://bit.ly/7neXaw
@mumsmarmie It's @Mulder_Cat who is getting chemo and taking prednisolone for a lymphosarcoma. He seems to be improving as well.
Scully_Cat (Scully_Cat) Sat, 02 Jan 2010 16:35:24 -0000
@mumsmarmie It's @Mulder_Cat who is getting chemo and taking prednisolone for a lymphosarcoma. He seems to be improving as well.
@Petiethecat I know Pepcid helped reduce the number of barfisodes I was having, although chemo and prednisolone have been more effective.
Mulder_Cat (Mulder_Cat) Sat, 02 Jan 2010 16:07:40 -0000
@Petiethecat I know Pepcid helped reduce the number of barfisodes I was having, although chemo and prednisolone have been more effective.
Happy new year to everyone. I'm starting it with a healthy dose of Prednisolone steroids to ease some discomfort before the infliximab.
CrohnsSufferer (CrohnsSufferer) Fri, 01 Jan 2010 17:44:16 -0000
Happy new year to everyone. I'm starting it with a healthy dose of Prednisolone steroids to ease some discomfort before the infliximab.

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