History

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Praziquantel was developed in the laboratories for parasitological research of Bayer AG in Germany (Elberfeld) 30 years ago (in the mid 1970's). Since then it has proven indispensable in more and more indications and is recognized as such by the World Health Organization.

Pharmacokinetics

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Praziquantel is well (approximately 80%) absorbed from the GI Tract. Due to extensive first pass metabolization only relatively small amounts enter systemic circulation. Praziquantel has a serum halflife of 0.8 to 1.5 hours (metabolites 4 to 5 hours) in adults with normal renal and liver function. In patients with significantly impaired liver function (Child Pugh classes B and C) the serum halflife is increased to 3 to 8 hours. Praziquantel and its metabolites are mainly excreted in the urine, within 24 hours after a single oral dose 70 to 80% are recovered in urine, but less than 0.1% are found as the unchanged drug.

Mode of Action

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Although the mode of action is not exactly known presently, there is experimental evidence that Praziquantel increases the permeability of the membranes of parasite cells (certain schistosomes) for calcium ions. The drug thereby induces contraction of the parasites resulting in paralysis in the contracted state. The dying parasites are dislodged from their site of action in the host organism and may enter systemic circulation or may be destroyed by host immune reaction (phagocytosis). Additional mechanisms - focal disintegrations and disturbances of oviposition (laying of eggs) - are seen in other types of sensitive parasites.

More on [ Praziquantel ]

Praziquantel - Twitter Search

Hoy voy a ir a comprar Praziquantel para los Dipylidium caninum de mi mascota, el mismo dia mi madre hace spaghetti a la bolognesa.
anarbol (Anarbol Leal) Wed, 09 Dec 2009 20:21:12 -0000
Hoy voy a ir a comprar Praziquantel para los Dipylidium caninum de mi mascota, el mismo dia mi madre hace spaghetti a la bolognesa.
@suckahpunch Ours ferals get Praziquantel & Revolution during s/n which works great, the adoptables in the shelter are the problems w/mites.
_MKF_ (Monica Frenden) Wed, 09 Dec 2009 16:08:27 -0000
@suckahpunch Ours ferals get Praziquantel & Revolution during s/n which works great, the adoptables in the shelter are the problems w/mites.
@svbarbara as vezes eu vejo o medicamento e me pergunto qual que usa esse tbm...(qndo n é praziquantel nem albendazol) eu lembro do ciclo
PattyNakazone (Patty Nakazone) Wed, 09 Dec 2009 03:51:59 -0000
@svbarbara as vezes eu vejo o medicamento e me pergunto qual que usa esse tbm...(qndo n é praziquantel nem albendazol) eu lembro do ciclo
Effect of Cyclodextrin Complexation on the Aqueous Solubility and Solubility/Dose Ratio of Praziquantel http://kele.es/mLJ
Sciencia (Webmaster Sciencia) Sat, 05 Dec 2009 02:00:50 -0000
Effect of Cyclodextrin Complexation on the Aqueous Solubility and Solubility/Dose Ratio of Praziquantel http://kele.es/mLJ
trtmt of ppl w/ cysticercosis w/ praziquantel or albndazole http://bit.ly/5KDKzl
dctrials (dc trials) Thu, 03 Dec 2009 04:55:12 -0000
trtmt of ppl w/ cysticercosis w/ praziquantel or albndazole http://bit.ly/5KDKzl
Albendazol,Ivermectina,Abamectina,citrato e cloreto colina, streptomicina praziquantel,p.pirantel,vitamina C...(16) 3214.6564(11)6660.2028
Nilzavendas (Nilza Dias - Caste ) Thu, 03 Dec 2009 03:47:34 -0000
Albendazol,Ivermectina,Abamectina,citrato e cloreto colina, streptomicina praziquantel,p.pirantel,vitamina C...(16) 3214.6564(11)6660.2028

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