Pramipexole (Mirapex) is a medication indicated for treating Parkinson's disease. Off-label uses include treatment for cluster headache and restless legs syndrome (RLS). Pramipexole has shown robust effects on pilot studies in bipolar depression. Pramipexole is classified as a non-ergoline dopamine agonist.

Mechanism of action

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The basal ganglia is a region of the human brain involved in the regulation of body movement; hence, when components of the basal ganglia are damaged, disorders of body movement may occur.

Parkinson's disease is a neurodegenerative disease affecting the substantia nigra, a component of the basal ganglia. The substantia nigra has a high quantity of dopaminergic neurons, which are neurons that release the neurotransmitter known as dopamine. When dopamine is released, it may activate dopamine receptors in the striatum, which is another component of the basal ganglia. When neurons of the substantia nigra deteriorate in Parkinson's disease, the striatum no longer receives dopamine signals. As a result, the basal ganglia can no longer regulate body movement effectively and motor function becomes impaired.

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Pramipexole vs. Levodopa for the best form of PD treatment ??? #Biologyissuereportblowme
LiamChong92 (Liam Chong) Thu, 02 Feb 2012 16:32:39 -0000
Pramipexole vs. Levodopa for the best form of PD treatment ??? #Biologyissuereportblowme
RT @selleckchem: Pramipexole (Mirapex) | CAS 104632-26-0 | Dopamine receptor Inhibitor | Mirapexin, Sifrol http://t.co/DIZZGmfv
abbyabbie7 (abbyabbie) Wed, 01 Feb 2012 02:46:54 -0000
RT @selleckchem: Pramipexole (Mirapex) | CAS 104632-26-0 | Dopamine receptor Inhibitor | Mirapexin, Sifrol http://t.co/DIZZGmfv
Pramipexole Conversion to Ropinirole CR http://t.co/5XF8uOVV
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