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Podophyllotoxin, otherwise known as podofilox is a non-alkaloid toxin of molecular weight 414.40 and a formula of C22 H22 O8 .present at concentrations of 0.3 to 1.0% by mass in the rhizome of American Mayapple Podophyllum peltatum. The melting point of Podophyllotoxin is 183.3 - 184.0 degrees C. Podophyllotoxin is the pharmacological base for the important anti-cancer drug Etoposide. It is also used as a gel or solution to treat warts.

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