Pilocarpine is a muscarinic alkaloid obtained from the leaves of tropical American shrubs from the genus Pilocarpus. It acts as a muscarinic receptor agonist in the parasympathetic nervous system.

Clinical uses

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Pilocarpine has been used in the treatment of chronic open-angle glaucoma and acute angle-closure glaucoma for over 100 years.^* It acts on a subtype of muscarinic receptor (M₃) found on the iris sphincter muscle, causing the muscle to contract and produce miosis. This opens the trabecular meshwork through increased tension on the scleral spur. This action facilitates the rate that aqueous humor leaves the eye to decrease intraocular pressure.

Pilocarpine is also used to treat dry mouth (xerostomia). Pilocarpine stimulates the secretion of large amounts of saliva and sweat. It may also cause hypotension and bradycardia in the cardiovascular system, and bronchospasm and increased bronchial secretion in the lungs due to its non-selective muscarinic action.

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acupuncture-like transcutaneous electrical nerve stimulation or pilocarpine in treating early dry mouth in ppl http://bit.ly/5Ct54a
localtrials (US Clinical Trials ) Mon, 23 Nov 2009 13:18:07 -0000
acupuncture-like transcutaneous electrical nerve stimulation or pilocarpine in treating early dry mouth in ppl http://bit.ly/5Ct54a
acupuncture-like transcutaneous electrical nerve stimulation or pilocarpine in treating early dry mouth in ppl http://bit.ly/5Ct54a
usclinicaltrial (US Clinical Trials) Sun, 22 Nov 2009 14:03:31 -0000
acupuncture-like transcutaneous electrical nerve stimulation or pilocarpine in treating early dry mouth in ppl http://bit.ly/5Ct54a
acupuncture-like transcutaneous electrical nerve stimulation or pilocarpine in treating early dry mouth in ppl http://bit.ly/5Ct54a
recruitingtrial (Recruiting Trials) Sun, 22 Nov 2009 12:33:49 -0000
acupuncture-like transcutaneous electrical nerve stimulation or pilocarpine in treating early dry mouth in ppl http://bit.ly/5Ct54a
acupuncture-like transcutaneous electrical nerve stimulation or pilocarpine in treating early dry mouth in ppl http://bit.ly/5XlNOd
cancertrials_ (Cancer Trials) Sun, 22 Nov 2009 01:34:55 -0000
acupuncture-like transcutaneous electrical nerve stimulation or pilocarpine in treating early dry mouth in ppl http://bit.ly/5XlNOd
Muscarinic cholinoceptor activation by pilocarpine triggers apoptosis in human skin fibroblast cells http://kele.es/kI6
Bio_Network (George Maine) Sun, 22 Nov 2009 00:30:56 -0000
Muscarinic cholinoceptor activation by pilocarpine triggers apoptosis in human skin fibroblast cells http://kele.es/kI6
acupuncture-like transcutaneous electrical nerve stimulation or pilocarpine in treating early dry mouth in ppl http://bit.ly/8gkTX6
bostontrials (Boston Trials) Sat, 21 Nov 2009 23:03:54 -0000
acupuncture-like transcutaneous electrical nerve stimulation or pilocarpine in treating early dry mouth in ppl http://bit.ly/8gkTX6

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