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Phenytoin sodium (marketed as Dilantin® in the USA and as Epanutin® in the UK, by Parke-Davis, now part of Pfizer) is a commonly used antiepileptic. It was approved by the Food and Drug Administration in 1953 for use in seizures. Phenytoin acts to damp the unwanted, runaway brain activity seen in seizure by reducing electrical conductance among brain cells.
History
Phenytoin (diphenylhydantoin) was first synthesized by a German physician named Heinrich Biltz in 1908. Biltz sold his discovery to Parke-Davis, which did not find an immediate use for it. In 1938, outside scientists including H. Houston Merritt and Tracy Putnam discovered phenytoin's usefulness for controlling seizures, without the sedation effects associated with phenobarbital. There are some indications that phenytoin has other effects, including anxiety control and mood stabilization, although it has never been approved for those purposes by the FDA.
Jack Dreyfus, founder of the Dreyfus Fund, became a major proponent of phenytoin as a means to control nervousness and depression when he received a prescription for Dilantin in 1966. Dreyfus' book about his experience with phenytoin, A Remarkable Medicine Has Been Overlooked, sits on the shelves of many physicians courtesy of the work of his foundation. Despite more than $70 million in personal financing, his push to see phenytoin evaluated for alternative uses has had little lasting effect on the medical community. This was partially due to Parke-Davis's reluctance to invest in a drug nearing the end of its patent life, and partially due to mixed results from various studies.
More on [ Phenytoin ]
is now in HDU on phenytoin to try to break his seizure cycle. He is very drowsy from the huge amount of drugs he's... http://bit.ly/8gJsRm
LewisJeynes (Lewis Jeynes) Fri, 04 Dec 2009 11:46:28 -0000
is now in HDU on phenytoin to try to break his seizure cycle. He is very drowsy from the huge amount of drugs he's... http://bit.ly/8gJsRm
EMEA PhVWP monthly report â Nov 2009 recommends ... for oral phenytoin ...of Stevens-Johnson syndrome in patients ...http://bit.ly/6oBz33
PharmacoBlogie (PharmacoBlogie) Mon, 30 Nov 2009 18:16:41 -0000
EMEA PhVWP monthly report – Nov 2009 recommends ... for oral phenytoin ...of Stevens-Johnson syndrome in patients ...http://bit.ly/6oBz33
GPnotebook: Phenytoin - Offers information on dose, side effects, alcohol reactions, monitoring levels, and other anticonvulsant drugs.
Jack Dreyfus and the Story of a Remarkable Medicine - It concerns Jack's efforts to cure himself of depression and his discovery of Dilantin. Includes clinical studies and a free book.
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