Phenylephrine or neosynephrine is an α-adrenergic receptor agonist used primarily as a decongestant, as an agent to dilate the pupil, and rarely to increase blood pressure. It has the CAS number 61-76-7.

Uses

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Decongestant

Phenylephrine is used as a decongestant, available as an oral medicine or as a nasal spray. Phenylephrine is not the most common over-the-counter (OTC) decongestant; oxymetazoline is a more common nasal spray. Pseudoephedrine has generally been a more common oral decongestant, although this is changing; pseudoephedrine's notoriety as a methamphetamine precursor has led governments around the world to restrict its sale.

Oral phenylephrine is extensively metabolised by monoamine oxidase, an enzyme which is present in the stomach and liver. Therefore, compared to orally-taken pseudoephedrine, it has a reduced bioavailability, and is less effective as a nasal decongestant. Because phenylephrine is a direct selective alpha-adrenergic receptor agonist, it does not cause the release of endogeneous noradrenaline like pseudoephedrine does. Therefore, phenylephrine is less likely to cause side-effects like central nervous system stimulation, insomnia, anxiety, irritability and restlessness.

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sciencestage.com Epinephrine, phenylephrine, and methoxamine induce infiltrative anesthesia vi.. http://bit.ly/1ArhqB
meeetweeet (meeetweeet) Sat, 07 Nov 2009 13:11:10 -0000
sciencestage.com Epinephrine, phenylephrine, and methoxamine induce infiltrative anesthesia vi.. http://bit.ly/1ArhqB
This explains my insomnia and restlessness over the last few weeks! Phenylephrine in my cold medicine.
alfberry (alfberry) Fri, 06 Nov 2009 23:10:32 -0000
This explains my insomnia and restlessness over the last few weeks! Phenylephrine in my cold medicine.
It would be nice if phenylephrine actually worked. I might try to get hold of some pseudoephedrine on the way home.
colin_zr (colin z robertson) Wed, 04 Nov 2009 14:43:01 -0000
It would be nice if phenylephrine actually worked. I might try to get hold of some pseudoephedrine on the way home.
@ionuca Biofarm (paracetamol+dextrometorfan+pseudoefedrina+clorfeniramina) sau străin (parac+clorf+phenylephrine), nici o treabă cu teina.
beranger_v4 (Béranger) Tue, 03 Nov 2009 15:37:41 -0000
@ionuca Biofarm (paracetamol+dextrometorfan+pseudoefedrina+clorfeniramina) sau străin (parac+clorf+phenylephrine), nici o treabă cu teina.
I choose you, Phenylephrine hydrochloride!
opticblast (Alex Berg) Tue, 03 Nov 2009 14:14:41 -0000
I choose you, Phenylephrine hydrochloride!
kinda sick still...in 1000mg Phenylephrine HCl...
hellohellocarlo (carl silverio) Mon, 02 Nov 2009 15:12:04 -0000
kinda sick still...in 1000mg Phenylephrine HCl...

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