Phenylephrine or neosynephrine is an α-adrenergic receptor agonist used primarily as a decongestant, as an agent to dilate the pupil, and rarely to increase blood pressure. It has the CAS number 61-76-7.

Uses

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Decongestant

Phenylephrine is used as a decongestant, available as an oral medicine or as a nasal spray. Phenylephrine is not the most common over-the-counter (OTC) decongestant; oxymetazoline is a more common nasal spray. Pseudoephedrine has generally been a more common oral decongestant, although this is changing; pseudoephedrine's notoriety as a methamphetamine precursor has led governments around the world to restrict its sale.

Oral phenylephrine is extensively metabolised by monoamine oxidase, an enzyme which is present in the stomach and liver. Therefore, compared to orally-taken pseudoephedrine, it has a reduced bioavailability, and is less effective as a nasal decongestant. Because phenylephrine is a direct selective alpha-adrenergic receptor agonist, it does not cause the release of endogeneous noradrenaline like pseudoephedrine does. Therefore, phenylephrine is less likely to cause side-effects like central nervous system stimulation, insomnia, anxiety, irritability and restlessness.

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@roxytweets Oh.. or anything that has Phenylephrine HCl + Chlorphenamine maleate + Paracetamol.. LoL
c2d_fourth (Chona Cherry Cepeda) Sun, 06 Dec 2009 08:12:22 -0000
@roxytweets Oh.. or anything that has Phenylephrine HCl + Chlorphenamine maleate + Paracetamol.. LoL
RT @supercujo: They should really tell you phenylephrine works better when you consume alcohol <~~ haha!!
Kendylahlah (Kendal Hammond) Sat, 05 Dec 2009 01:13:33 -0000
RT @supercujo: They should really tell you phenylephrine works better when you consume alcohol <~~ haha!!
They should really tell you phenylephrine works better when you consume alcohol
supercujo (supercujo) Fri, 04 Dec 2009 23:47:08 -0000
They should really tell you phenylephrine works better when you consume alcohol
Chlorpheniramine Maleate, Phenylephrine HCl, Noscapine, and Bromhexene HCl. Hope this means I can sleep tonight.
skinnypupp (Carl Nelson) Fri, 04 Dec 2009 18:55:43 -0000
Chlorpheniramine Maleate, Phenylephrine HCl, Noscapine, and Bromhexene HCl. Hope this means I can sleep tonight.
@stevewollaston Lemsips are useless. Phenylephrine Hydrochloride is shown to have no more than a placebo effect. Fluids and rest dude
almajir (almajir) Fri, 04 Dec 2009 09:36:44 -0000
@stevewollaston Lemsips are useless. Phenylephrine Hydrochloride is shown to have no more than a placebo effect. Fluids and rest dude
This crap you are trying to make us switch to called phenylephrine DOES NOT WORK. So don't take your drug issues out on me!
talk2jorgelopez (talk2jorgelopez) Thu, 03 Dec 2009 23:13:33 -0000
This crap you are trying to make us switch to called phenylephrine DOES NOT WORK. So don't take your drug issues out on me!

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