Phenelzine (sold as Nardil®) is a monoamine oxidase inhibitor (MAOI) used as an antidepressant drug.

Mode of action

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Phenelzine is a derivative of hydrazine, which is phenylethylamine-like moiety and similar to normal substrates of MAO. When MAO tries to oxidize phenelzine, this hydrazine-moiety binds covalently to the enzyme, thus inactivating it irreversibly. Phenelzine is a non-selective MAO-inhibitor, it inhibits both MAO-A and MAO-B. Furthermore, primarily through its primary metabolite, PEH (phenylethylidenehydrazine), phenelzine elevates levels of GABA in the caudate-putamen and nucleus accumbens. This may contribute to its anxiolytic properties and superior efficiacy in treating severe anxiety.

Pharmacokinetics

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Phenelzine is administered orally as phenelzine sulphate and it is rapidly absorbed form the gastro-intestinal tract. Although phenelzine has a fairly short half-life, its effect lasts for several weeks, until new functional MAO-enzymes have been produced by the body. Phenelzine is acetylated in the liver and its metabolites are excreted in the urine.

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Nardil Withdrawal: If you suddenly stop taking Nardil (phenelzine), there is a risk of experiencing withdrawal symp... http://bit.ly/5yqME4
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