Perphenazine is a typical antipsychotic drug. Chemically, it is classified as a piperazinyl phenothiazine. It has been in clinical use for decades.

Perphenazine is 10 to 15 times as potent as chlorpromazine; that means perphenazine is a highly potent antipsychotic. In equivalent doses it has approximately the same frequency and severity of early and late extrapyramidal side-effects compared to Haloperidol.

Pharmacokinetics

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It has an oral bioavailability of approximately 40% and a halflife of 8 to 12 hours (up to 20 hours), and is usually given in 2 or 3 diveded doses each day. It is possible to give 2/3 of the daily dose at bedtime and 1/3 during breakfast to maximize hypnotic activity during the night and to minimize daytime sedation and hypotension without loss of therapeutic activity. It has a high incidence of early and late extrapyramidal side-effects (tardive dyskinesia).

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