Penicillamine is a pharmaceutical of the chelator class. It is sold under the trade names of Cuprimine and Depen. The pharmaceutical form is D-penicillamine, as L-penicillamine is toxic (it inhibits the action of pyridoxine). It is a metabolite of penicillin, although it has no antibiotic properties.

Uses

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Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking.

It is used as a chelating agent:

• In Wilson's disease, a rare genetic disorder of copper metabolism, penicillamine treatment relies on its binding to accumulated copper and elimination through urine.
• In cystinuria, a hereditary disorder featuring increased cystine excretion, penicillamine binds with the cystine to make it more soluble.

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Drugs such as penicillamine, hydralazine, isoniazid, chlorpromazine, methyldopa, procainamide may cause drug-induced lupus
mswede64 (mswede) Tue, 27 Dec 2011 15:20:25 -0000
Drugs such as penicillamine, hydralazine, isoniazid, chlorpromazine, methyldopa, procainamide may cause drug-induced lupus
@step1quizz Wilson's disease,chelating agents :penicillamine , trientine
hedi6788 (hedi) Thu, 22 Dec 2011 01:29:02 -0000
@step1quizz Wilson's disease,chelating agents :penicillamine , trientine

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