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Pemetrexed (brand name Alimta) is a chemotherapy drug. Its indications are the treatment of pleural mesothelioma as well as non-small cell lung cancer.
Mechanism of action
Pemetrexed is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting three enzymes used in purine and pyrimidine synthesis—thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyl transferase (GARFT). By inhibiting the formation of precursor purine and pyrimidine nucleotides, pemetrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.
The molecular structure of pemetrexed was developed by Edward C. Taylor at Princeton University and clinically developed by Indianapolis based drug maker, Eli Lilly and Company.
More on [ Pemetrexed ]
#pharma Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-ce... http://bit.ly/8yhrJe
ExpertOpinion (Expert Opinion) Thu, 07 Jan 2010 06:08:09 -0000
#pharma Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-ce... http://bit.ly/8yhrJe
Chemotherapy: Asbestos: Mesothelioma Study on Pemetrexed Finds the Chemotherapy ... http://bit.ly/4qQsJm
lefernald (Fernald Leeanne) Sun, 03 Jan 2010 18:56:07 -0000
Chemotherapy: Asbestos: Mesothelioma Study on Pemetrexed Finds the Chemotherapy ... http://bit.ly/4qQsJm
Latest medical news: Mesothelioma Study on Pemetrexed Finds the Chemotherapy Drug to be S... www.medoodle.com/i.cgi?j=&i=20100102-17
medical_network (Medical network) Sat, 02 Jan 2010 22:04:53 -0000
Latest medical news: Mesothelioma Study on Pemetrexed Finds the Chemotherapy Drug to be S... www.medoodle.com/i.cgi?j=&i=20100102-17
pemetrexed and/or sunitinib as 2nd-line thrpy in treating ppl w/ stage iiib or stage iv non-small cell lung cancer http://bit.ly/92ZFha
newtrials_ (New Clinical Trials) Sat, 02 Jan 2010 05:50:24 -0000
pemetrexed and/or sunitinib as 2nd-line thrpy in treating ppl w/ stage iiib or stage iv non-small cell lung cancer http://bit.ly/92ZFha
pemetrexed and/or sunitinib as 2nd-line thrpy in treating ppl w/ stage iiib or stage iv non-small cell lung cancer http://bit.ly/92ZFha
paidtrials (US Clinical Trials) Sat, 02 Jan 2010 05:42:25 -0000
pemetrexed and/or sunitinib as 2nd-line thrpy in treating ppl w/ stage iiib or stage iv non-small cell lung cancer http://bit.ly/92ZFha
pemetrexed and/or sunitinib as 2nd-line thrpy in treating ppl w/ stage iiib or stage iv non-small cell lung cancer http://bit.ly/92ZFha
localtrials (US Clinical Trials ) Sat, 02 Jan 2010 05:42:22 -0000
pemetrexed and/or sunitinib as 2nd-line thrpy in treating ppl w/ stage iiib or stage iv non-small cell lung cancer http://bit.ly/92ZFha
Alimta.com - Lilly - Official pharmaceutical site with information for patients and health professionals.
Meta Description: [ Eli Lilly provides information on ALIMTA, approved as a single-agent for the treatment of non-small cell lung cancer and in combination with cisplatin by the FDA for the treatment of malignant pleural mesothelioma. Includes therapy options, FAQ's, safety information, and links to cancer resources. ]
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