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Pemetrexed (brand name Alimta) is a chemotherapy drug. Its indications are the treatment of pleural mesothelioma as well as non-small cell lung cancer.
Mechanism of action
Pemetrexed is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting three enzymes used in purine and pyrimidine synthesis—thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyl transferase (GARFT). By inhibiting the formation of precursor purine and pyrimidine nucleotides, pemetrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.
The molecular structure of pemetrexed was developed by Edward C. Taylor at Princeton University and clinically developed by Indianapolis based drug maker, Eli Lilly and Company.
More on [ Pemetrexed ]
Alimta.com - Lilly - Official pharmaceutical site with information for patients and health professionals.
Meta Description: [ Eli Lilly provides information on ALIMTA, approved as a single-agent for the treatment of non-small cell lung cancer and in combination with cisplatin by the FDA for the treatment of malignant pleural mesothelioma. Includes therapy options, FAQ's, safety information, and links to cancer resources. ]
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