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Orlistat (marketed as Xenical by Roche) is a drug designed to treat obesity. Its primary function is to prevent the absorption of dietary fats, thereby reducing caloric intake. It is intended for use in conjunction with a physician-supervised reduced calorie diet.
Pharmacology
Orlistat works by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested. Only trace amounts of orlistat are absorbed systemically, the primary effect is local lipase inhibition within the GI tract after an oral dose. The primary route of elimination is through the feces.
At the standard prescription dose of 120 mg three times daily before meals, orlistat prevents approximately 30% of dietary fat from being absorbed.
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Xenical - Official site from Roche, containing information for consumers and health care professionals.
Meta Description: [ Xenical.com provides the information and tools needed to talk to your doctor about developing a weight loss program and reaching your health goals. ]
Diabetes News - Orlistat chosen as weight-loss drug for Look AHEAD study, the first long-term study of weight loss' effects in people with type 2 diabetes. (August 2001)
Meta Description: [ Explore articles to learn more about diabetes, discover ways to eat healthier, work more activity into your daily life and keep your blood sugar in check. ]
DrugDigest: Orlistat ( Xenical ) - Information on dosage, usage, side effects, interactions, and drug comparisons, including generics when available.
Drugs.com - Consumer information for Xenical.
Elderly and Xenical - Summary of study findings among obese elderly people taking Xenical.
FDA Approves Orlistat - FDA Talk Paper regarding approval of Orlistat (Xenical).
Meta Description: [ FDA APPROVES ORLISTAT FOR OBESITY ]
FDA Consumer Information - FDA review of Xenical (orlistat) and links to labeling and patient information.
Long-Term Effects - Study shows that weight lost with Xenical stays off for 2 years and reduces disease risk factors.
Obesity Meds and Research News - Newsletter with the latest on pharmacotherapy and research into obesity's causes/cures.
Meta Description: [ The only newsletter and web site of its kind with plain-language information on obesity medications, weight loss and diet studies written for professionals and patients. ]
Orlistat and Cholesterol - Professional abstract of Washington University study showing orlistat inhibits cholesterol absorption.
Orlistat in type 2 diabetes - Roche reports that in Xenical study of people with type 2 diabetes, improvements in glycemic control and cardiovascular risk factors were observed, and the need for insulin and oral diabetes medications reduced. (24 May 2002)
Pharmacology of Xenical (orlistat) - Professional article with in-depth section on orlistat's pharmacology, clinical trial results and side effects, from the Endocrine Society.
Washington University Medical News - Washington University Study shows orlistat blocks cholesterol absorption in obese people. November 1, 2000.
Xenical - The official Roche New Zealand site for Xenical
Xenical Central - Xenical consumer information, news releases and online pharmacy reviews.
Meta Description: [ Complete consumer information about Xenical. ]
Xenical News.com - Provides general advice for people looking to lose weight and more specialized information for people taking part in the Xenical Weight Loss Program.
Xenical Webcentre - The Roche Australia Xenical site, includes product information for consumers and medical professionals.
Xenical: Patient Information - The Roche Xenical data sheet and important patient information.
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