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Ondansetron (INN) (IPA: ) is a serotonin 5-HT3 receptor antagonist used mainly to treat nausea and vomiting following chemotherapy. Its effects are thought to be on both peripheral and central nerves. One part is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata, the other is a blockage of serotonin receptors in the chemoreceptor trigger zone. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors.
The drug is administered 1–3 times daily, depending on the severity of nausea and/or vomiting. The normal dose for adults and children over the age of 12, is 8mg initially, followed by a second dose of 8mg, eight hours later. The drug is then administered once every 12 hours, usually not for more than 2-3 days. Following oral administration, it takes about 1.5–2 hours to reach maximum plasma concentrations. This drug is removed from the body by the liver and kidneys.
It is currently marketed by GlaxoSmithKline (GSK) under the trade name Zofran; other manufacturers include Cipla Ltd (Emeset), Chemical Works of Gedeon Richter (Emetron), and Zentiva a.s. (Ondemet). On May 29, 2006, Baxter Healthcare received tentative approval * to market its own label of Ondansetron Injection, USP, 8 mg/50 mL and 32 mg/50 mL iso-osmotic sodium chloride solution, after GSK's patent expires on December 24, 2006.
More on [ Ondansetron ]
New admit to hospice unit - panc CA - intractable N/V - will trial haloperidol standing - ondansetron prn. pt still full code... mtg in AM
Palliative_MD (Adam Herman) Thu, 05 Nov 2009 01:27:53 -0000
New admit to hospice unit - panc CA - intractable N/V - will trial haloperidol standing - ondansetron prn. pt still full code... mtg in AM
@DCharlton70 have u tried ondansetron? (zofran) ask ur doc about it. they use it to treat nausea from chemo treatments
NurseStacy (Stacy Craven) Wed, 04 Nov 2009 23:19:31 -0000
@DCharlton70 have u tried ondansetron? (zofran) ask ur doc about it. they use it to treat nausea from chemo treatments
DrugDigest: Ondansetron ( Zofran ) - Information on dosage, usage, side effects, interactions, and drug comparisons including generics when available.
Zofran - A medicine from GlaxoSmithKline used for the prevention of nausea and vomiting related to radiation therapy, cancer chemotherapy, and surgery.
Meta Description: [ ZOFRAN can help you and your healthcare professional prevent nausea and vomiting ]
