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Ondansetron (INN) (IPA: ) is a serotonin 5-HT3 receptor antagonist used mainly to treat nausea and vomiting following chemotherapy. Its effects are thought to be on both peripheral and central nerves. One part is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata, the other is a blockage of serotonin receptors in the chemoreceptor trigger zone. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors.
The drug is administered 1–3 times daily, depending on the severity of nausea and/or vomiting. The normal dose for adults and children over the age of 12, is 8mg initially, followed by a second dose of 8mg, eight hours later. The drug is then administered once every 12 hours, usually not for more than 2-3 days. Following oral administration, it takes about 1.5–2 hours to reach maximum plasma concentrations. This drug is removed from the body by the liver and kidneys.
It is currently marketed by GlaxoSmithKline (GSK) under the trade name Zofran; other manufacturers include Cipla Ltd (Emeset), Chemical Works of Gedeon Richter (Emetron), and Zentiva a.s. (Ondemet). On May 29, 2006, Baxter Healthcare received tentative approval * to market its own label of Ondansetron Injection, USP, 8 mg/50 mL and 32 mg/50 mL iso-osmotic sodium chloride solution, after GSK's patent expires on December 24, 2006.
More on [ Ondansetron ]
pilot stdy 2 assess palonosetron vs ondansetron as rescue medication in ppl tht develop postoperative nausea & vomiting http://bit.ly/77zw6t
localtrials (US Clinical Trials ) Sat, 19 Dec 2009 02:54:42 -0000
pilot stdy 2 assess palonosetron vs ondansetron as rescue medication in ppl tht develop postoperative nausea & vomiting http://bit.ly/77zw6t
pilot stdy 2 assess palonosetron vs ondansetron as rescue medication in ppl tht develop postoperative nausea & vomiting http://bit.ly/77zw6t
usclinicaltrial (US Clinical Trials) Sat, 19 Dec 2009 02:34:41 -0000
pilot stdy 2 assess palonosetron vs ondansetron as rescue medication in ppl tht develop postoperative nausea & vomiting http://bit.ly/77zw6t
pilot stdy 2 assess palonosetron vs ondansetron as rescue medication in ppl tht develop postoperative nausea & vomiting http://bit.ly/77zw6t
recruitingtrial (Recruiting Trials) Sat, 19 Dec 2009 01:38:45 -0000
pilot stdy 2 assess palonosetron vs ondansetron as rescue medication in ppl tht develop postoperative nausea & vomiting http://bit.ly/77zw6t
ondansetron vs aprepitant + ondansetron 4 emesis http://bit.ly/5ScyAz
goclinicaltrial (Clinical Trials) Fri, 18 Dec 2009 23:30:39 -0000
ondansetron vs aprepitant + ondansetron 4 emesis http://bit.ly/5ScyAz
ondansetron vs aprepitant + ondansetron 4 emesis http://bit.ly/5ScyAz
newtrials_ (New Clinical Trials) Fri, 18 Dec 2009 23:14:43 -0000
ondansetron vs aprepitant + ondansetron 4 emesis http://bit.ly/5ScyAz
Generic Zofran (ondansetron) is now available from @HealthWarehouse. Only $22 for 30 tablets and FREE shipping! http://bit.ly/zofran
ElderAssist (HealthWarehouse.com) Fri, 18 Dec 2009 18:56:22 -0000
Generic Zofran (ondansetron) is now available from @HealthWarehouse. Only $22 for 30 tablets and FREE shipping! http://bit.ly/zofran
DrugDigest: Ondansetron ( Zofran ) - Information on dosage, usage, side effects, interactions, and drug comparisons including generics when available.
Zofran - A medicine from GlaxoSmithKline used for the prevention of nausea and vomiting related to radiation therapy, cancer chemotherapy, and surgery.
Meta Description: [ ZOFRAN can help you and your healthcare professional prevent nausea and vomiting ]
