Nitrofurantoin is an antibiotic drug. It is only useful in the treatment of cystitis.

Pharmacology

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Organisms are said to be susceptible to nitrofurantoin if their MIC is 32mcg/ml or less. The peak blood concentration of nitrofurantoin following an oral dose of nitrofurantoin 100mg, is less than 1 microgram/ml and may be undetectable; tissue penetration is negligible; the drug is well concentrated in the urine: 75% of the dose is rapidly metabolised by the liver, but 25% of the dose is excreted in the urine unchanged, reliably achieving levels of 200 μg/ml or more. For this reason, nitrofurantoin cannot be used to treat anything other than simple cystitis.

At the concentrations achieved in urine, nitrofurantoin is bacteriocidal. The mechanism of action of nitrofurantoin is unique and complex. The drug works by damaging bacterial DNA, since its reduced form is highly reactive. This is made possible by the rapid reduction of nitrofurantoin inside the bacterial cell by flavoproteins (nitrofuran reductase) to multiple reactive intermediates that attack ribosomal proteins, DNA respiration, pyruvate metabolism and other macromolecules within the cell. It is not known which of the actions of nitrofurantoin is primarily responsible for its bacteriocidal acitivity.

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Latest Topics: premarin, extacy pills, avinza, sertraline, mexico pharmacy, librium, m in a square, clonazepam, nitrofurantoin, 11, Reglan,
druginfo (Medicine Community) Fri, 06 Nov 2009 07:30:07 -0000
Latest Topics: premarin, extacy pills, avinza, sertraline, mexico pharmacy, librium, m in a square, clonazepam, nitrofurantoin, 11, Reglan,
Nitrofurantoin monohydrate #whoneedskidneysanyway
thelittlebrier (Leah Brier) Wed, 04 Nov 2009 19:35:39 -0000
Nitrofurantoin monohydrate #whoneedskidneysanyway
Sulfa drugs and nitrofurantoin associated with birth defects. Podcast later this week! Arch Pediatr Adolesc Med. 2009;163(11):978-985.
keepingupwithem (Keeping Up) Wed, 04 Nov 2009 16:07:56 -0000
Sulfa drugs and nitrofurantoin associated with birth defects. Podcast later this week! Arch Pediatr Adolesc Med. 2009;163(11):978-985.
- http://bit.ly/4wcN7N - All about Nitrofurantoin, 50mg, Tablet
GlueText (GlueText) Wed, 04 Nov 2009 03:24:20 -0000
- http://bit.ly/4wcN7N - All about Nitrofurantoin, 50mg, Tablet
The antibiotics sulfonamide & nitrofurantoin (used 2 treat urinary tract infections) have bn found 2 cause birth defects http://bit.ly/4BS2u
hysell (Hysell Oviedo) Tue, 03 Nov 2009 19:11:08 -0000
The antibiotics sulfonamide & nitrofurantoin (used 2 treat urinary tract infections) have bn found 2 cause birth defects http://bit.ly/4BS2u
Da macht jemand in einem UNIX-Forum für Nitrofurantoin Werbung: http://trunc.it/3151p Was denn noch?
migowa (Michael Gottwald) Sun, 01 Nov 2009 18:19:34 -0000
Da macht jemand in einem UNIX-Forum für Nitrofurantoin Werbung: http://trunc.it/3151p Was denn noch?

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