Niacin, also known as
nicotinic acid or
vitamin B3, is a water-soluble
vitamin whose derivatives such as
NADH, NAD, NAD
+, and NADP play essential roles in energy metabolism in the
living cell and
DNA repair. The designation
vitamin B3 also includes the
amide form,
nicotinamide or
niacinamide. Severe lack of niacin causes the deficiency disease
pellagra, whereas a mild deficiency slows down the
metabolism decreasing cold tolerance. The recommended daily allowance of niacin is 2-12 mg a day for children, 14 mg a day for women, 16 mg a day for men, and 18 mg a day for pregnant or breast-feeding women.
Discovery
Nicotinic acid was first discovered from the oxidation of
nicotine. When the properties of nicotinic acid were discovered, it was thought prudent to choose a name to dissociate it from nicotine and to avoid the idea that either smoking provided vitamins or that wholesome food contained a poison. The resulting name 'niacin' was derived from
nicotinic
acid + vitam
in.
Industrial use
Nicotinic acid reacts with
hemoglobin and
myoglobin in meat to form a brightly coloured complex, and thus has been used as a
food additive, typically to improve the colour of minced (ground) meat. Niacin is licensed as a food colouring agent in some, non-European, countries.
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Lipid Lowering Agents :: Drugs and Medications
Nicotinic Acid (Niacin) - Information about action as a lipid-lowering agent, side effects, contraindications, and other pharmacologic details.