Nesiritide (Natrecor®) is a medication used to treat acutely decompensated congestive heart failure with dyspnea at rest or with minimal exertion (such as talk, eating or bathing). A brain natriueretic peptide, nesiritide works to facilitate cardiovascular fluid homeostasis through counterregulation of the renin-angiotensin-aldoesterone system, stimulating cyclic guanosine monophosphate, leading to smooth muscle cell relaxation. In simpler terms, it promotes vasodilation, natriuresis, and diuresis.

Administration

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Nesiritide is only administered intravenously, usually by bolus, followed by IV infusion. For most adults and the elderly, a normal dosage is 2 micrograms/kilogram followed by a continuous IV infusion of 0.01 mcg/kg/minute. This may be increased every three hours for a maximum of 0.03 mcg/kg/min.

Side effects

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Common side effects include:

• Low blood pressure (11% of patients)
• Headache
• Nausea
• Slow heart rate

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Low-dose nesiritide explored as adjunct to MI reperfusion therapy- Nesiritide, the drug form of brain-type natriure... http://bit.ly/16cYFy
AnotherWhiteMug (anotherwhitemug.com) Wed, 12 Aug 2009 18:57:00 -0000
Low-dose nesiritide explored as adjunct to MI reperfusion therapy- Nesiritide, the drug form of brain-type natriure... http://bit.ly/16cYFy
RT @theheartorg: Low-dose nesiritide explored as adjunct to MI reperfusion therapy (Aug2009 issue of Heart) http://ow.ly/jPFI
CenterWatch (CenterWatch) Wed, 12 Aug 2009 16:51:11 -0000
RT @theheartorg: Low-dose nesiritide explored as adjunct to MI reperfusion therapy (Aug2009 issue of Heart) http://ow.ly/jPFI
heartwire: Low-dose nesiritide explored as adjunct to MI reperfusion therapy http://bit.ly/1OeIj9
theheartorg (Shelley Wood) Wed, 12 Aug 2009 16:38:25 -0000
heartwire: Low-dose nesiritide explored as adjunct to MI reperfusion therapy http://bit.ly/1OeIj9
Heartwire Low-dose nesiritide explored as adjunct to MI reperfusion therapy: Given at much lower dosage.. http://bit.ly/MUPQJ
medscapecardio (medscapecardio) Wed, 12 Aug 2009 16:19:53 -0000
Heartwire Low-dose nesiritide explored as adjunct to MI reperfusion therapy: Given at much lower dosage.. http://bit.ly/MUPQJ

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