Nesiritide (Natrecor®) is a medication used to treat acutely decompensated congestive heart failure with dyspnea at rest or with minimal exertion (such as talk, eating or bathing). A brain natriueretic peptide, nesiritide works to facilitate cardiovascular fluid homeostasis through counterregulation of the renin-angiotensin-aldoesterone system, stimulating cyclic guanosine monophosphate, leading to smooth muscle cell relaxation. In simpler terms, it promotes vasodilation, natriuresis, and diuresis.

Administration

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Nesiritide is only administered intravenously, usually by bolus, followed by IV infusion. For most adults and the elderly, a normal dosage is 2 micrograms/kilogram followed by a continuous IV infusion of 0.01 mcg/kg/minute. This may be increased every three hours for a maximum of 0.03 mcg/kg/min.

Side effects

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Common side effects include:

• Low blood pressure (11% of patients)
• Headache
• Nausea
• Slow heart rate

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stdy testing effectiveness of nesiritide in ppl w/ acute decompens8d heart failure http://bit.ly/8rCvQR
_clinical_trial (Clinical Trials) Fri, 01 Jan 2010 05:54:27 -0000
stdy testing effectiveness of nesiritide in ppl w/ acute decompens8d heart failure http://bit.ly/8rCvQR
stdy testing effectiveness of nesiritide in ppl w/ acute decompens8d heart failure http://bit.ly/8rCvQR
newtrials_ (New Clinical Trials) Fri, 01 Jan 2010 05:54:24 -0000
stdy testing effectiveness of nesiritide in ppl w/ acute decompens8d heart failure http://bit.ly/8rCvQR
stdy testing effectiveness of nesiritide in ppl w/ acute decompens8d heart failure http://bit.ly/8rCvQR
localtrials (US Clinical Trials ) Fri, 01 Jan 2010 05:54:23 -0000
stdy testing effectiveness of nesiritide in ppl w/ acute decompens8d heart failure http://bit.ly/8rCvQR
stdy testing effectiveness of nesiritide in ppl w/ acute decompens8d heart failure http://bit.ly/8rCvQR
recruitingtrial (Recruiting Trials) Fri, 01 Jan 2010 05:50:24 -0000
stdy testing effectiveness of nesiritide in ppl w/ acute decompens8d heart failure http://bit.ly/8rCvQR
stdy testing effectiveness of nesiritide in ppl w/ acute decompens8d heart failure http://bit.ly/8rCvQR
usclinicaltrial (US Clinical Trials) Fri, 01 Jan 2010 05:50:20 -0000
stdy testing effectiveness of nesiritide in ppl w/ acute decompens8d heart failure http://bit.ly/8rCvQR
stdy testing effectiveness of nesiritide in ppl w/ acute decompens8d heart failure http://bit.ly/8rCvQR
goclinicaltrial (Clinical Trials) Fri, 01 Jan 2010 05:46:31 -0000
stdy testing effectiveness of nesiritide in ppl w/ acute decompens8d heart failure http://bit.ly/8rCvQR

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