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Neostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. By interfering with the breakdown of acetylcholine, neostigmine indirectly stimulates both nicotinic and muscarinic receptors.

Clinical Uses


It is used to improve muscle tone in people with myasthenia gravis and routinely in anesthesia at the end of an operation to reverse the effects of non-depolarising muscle relaxants such as vecuronium.

It can also be used for urinary retention resulting from general anaesthetia and to treat curariform drug toxicity.

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Kitz-Wilson Mechanisms of Action of Neostigmine and Penicillin. http://t.co/RjRcLazF
SympoAnesthesia (Symposier Anesthesia) Sun, 05 Feb 2012 02:19:05 -0000
Kitz-Wilson Mechanisms of Action of Neostigmine and Penicillin. http://t.co/RjRcLazF
RT @curromir: Randomized comparison of sugammadex and neostigmine for reversal rocuronium-induced muscle relaxation in morbidly obese http://t.co/nErzMTSi
Andreinamiraldo (Andreina Miraldo) Wed, 01 Feb 2012 23:30:40 -0000
RT @curromir: Randomized comparison of sugammadex and neostigmine for reversal rocuronium-induced muscle relaxation in morbidly obese http://t.co/nErzMTSi
Randomized comparison of sugammadex and ne
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