.png | CAS_number = 7681-93-8 | ATC_prefix = A01 | ATC_suffix = AB10 | ATC_supplemental = , , , | PubChem = 441382 | DrugBank = APRD01136 | chemical_formula = C₃₃H₄₇NO₁₃ | molecular_weight = 665.725 g/mol | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | pregnancy_category = | legal_status = | routes_of_administration = }} Natamycin, also known as pimaricin, is a naturally occurring antimicrobial agent produced by the bacterium Streptomyces natalensis. It is a macrolide polyene antifungal drug used to treat fungal keratitis. It is especially effective against Aspergillus and Fusarium corneal infections.

It is used in the food industry as a preservative to inhibit fungal growth on cheese. It may be applied in a liquid spray or in powdered form on whole, shredded, or soft cheese, or applied on or in the wax covering of some cheeses.

As a food additive, it has E number E235.