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Mycophenolic acid (INN) (IPA: ) or mycophenolate is an immunosuppresant drug used to prevent rejection in organ transplantation. It was initially marketed as the prodrug mycophenolate mofetil (abbreviated MMF) to improve oral bioavailability. More recently, the salt mycophenolate sodium has also been introduced. Mycophenolic acid is commonly marketed under the trade names Cellcept (mycophenolate mofetil; Roche) and Myfortic (mycophenolate sodium; Novartis).
Pharmacokinetics/pharmacology
Mycophenolate is derived from the fungus Penicillium stoloniferum. Mycophenolate mofetil is metabolised in the liver to the active moiety mycophenolic acid. It inhibits inosine mononophosphate dehydrogenase, the enzyme which controls the rate of synthesis of guanine monophosphate in the de novo pathway of purine synthesis used in the proliferation of lymphocytes.
Mycophenolate is therefore a potent anti-proliferative, and can be used in place of the older anti-proliferative azathioprine. It is usually used as part of triple therapy including a calcineurin inhibitor (ciclosporin or tacrolimus) and prednisolone.
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Patients with lupus nephritis class III/IV should begin with either cyclophosphamide or mycophenolate mofetil. http://t.co/D6lW7nJT
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Patients with lupus nephritis class III/IV should begin with either cyclophosphamide or mycophenolate mofetil. http://t.co/D6lW7nJT
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Mycophenolate Mofetil - Information for patients in English and Spanish.
