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Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug and sells it worldwide (as the hydrochloride) under the brand name Avelox® (in some countries also Avalox®) for oral treatment. Each tablet contains 400mg. In most countries the drug is also available in parenteral form for intravenous infusion. Currently, the drug is very popular.
Mode of action
Like other fluoroquinolones, moxifloxacin inhibits the bacterial enzyme DNA gyrase (topoisomerase IV) and thus prevents supercoiling of bacterial DNA. This mechanism is lethal to susceptible bacteria. Moxifloxacin is often referred to as a chemotherapeutic drug because its mode of action has so far not been noted in any natural occurring or semi-synthetic antibiotic.
Distribution
Moxifloxacin is found in high concentrations in body tissues and fluids, such as saliva, nasal and bronchial secrets, sinus mucosa, skin blister fluid, subcutaneous and muscle tissues. Pus does not seem to inhibit the drug's potential to reach effective concentrations in infectious foci easily. More on [ Moxifloxacin ]
Antibiotics :: Drugs and Medications
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Avelox - Moxifloxacin HCl. Features product information for health care professionals and patients including prescribing information, FAQs, and press releases.
Meta Description: [ AveloxUSA.com provides information about the management of common adult respiratory tract infections for which AVELOX is indicated. ]
Avelox - Respiratory antibiotic and sinusitis relief. Includes professional and patient information.
Meta Description: [ Avelox is a prescription antibiotic used to treat common respiratory infections including bacterial sinusitis, bronchitis, and pneumonia in adults. Avelox is also used to treat skin and skin structure infections and complicated intra-abdominal infections due to certain bacteria. ]
Avelox Consumer Information - FDA - Patient FAQ in html format with a link to approved labeling (as pdf).
DrugDigest: Moxifloxacin ( Avelox ) - Information on dosage, usage, side effects, interactions, and drug comparisons, including generics when available.
| Insidermedicine in 60 - September 20, 2007 | |
